Chiral piperidines from acyclic amines via enantioselective, radical-mediated δ C-H cyanation.
Sign Up to like & getrecommendations! Published in 2019 at "Chem"
DOI: 10.1016/j.chempr.2019.09.010
Abstract: Piperidines are the most prevalent heterocycle found in medicines. Yet, while they are often chiral, there remain no robust methods for their asymmetric syntheses. To solve this challenge, we have interrupted the century-old Hofmann-Löffler-Freytag (HLF)… read more here.
Keywords: piperidines acyclic; chiral piperidines; amines via; cyanation ... See more keywords
An overview on the progress and development on metals/non-metal catalyzed cyanation reactions
Sign Up to like & getrecommendations! Published in 2018 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.09.058
Abstract: Abstract This review is based on the analysis of recent developments on cyanation reactions for the synthesis of nitriles (RCN) through transition metal mediated cyanation reaction as well as by using non-metal like iodine (transition… read more here.
Keywords: development metals; cyanation; progress development; overview progress ... See more keywords
An overview on the progress and development on the palladium catalyzed direct cyanation
Sign Up to like & getrecommendations! Published in 2021 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2020.119956
Abstract: Abstract Generation of the positive CN ion and the corresponding direct cyanation are both extremely important for cyanation of aromatic compounds. Hereby, we would like to report the simultaneous use of the new Pd nano-catalyst… read more here.
Keywords: development palladium; direct cyanation; palladium catalyzed; cyanation ... See more keywords
Cyanation of aryl halides and Suzuki-Miyaura coupling reaction using palladium nanoparticles anchored on developed biodegradable microbeads.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.157
Abstract: This work reports i) green synthesis of palladium nanoparticles (Pd NPs) on the developed biodegradable microbeads as stabilizers, featuring chitosan, agarose and beta-cyclodextrin, ii) investigation of the catalytic role of the Pd NPs prepared in… read more here.
Keywords: palladium nanoparticles; developed biodegradable; cyanation; biodegradable microbeads ... See more keywords
Enantioselective Remote C(sp3)-H Cyanation via Dual Photoredox and Copper Catalysis.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02008
Abstract: The remote C(sp3)-H cyanation of carboxamides has been described by merging photoredox and copper catalysis in a site-selective and enantiocontrolled manner. The protocol is the integration of photoinduced and nitrogen-centered radical-mediated intermolecular hydrogen atom transfer… read more here.
Keywords: remote sp3; copper; cyanation; sp3 cyanation ... See more keywords
Ni-Catalyzed C-H Cyanation of (Hetero)arenes with 2-Cyanoisothiazolidine 1,1-Dioxide as a Cyanation Reagent.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00468
Abstract: A nickel-catalyzed C-H cyanation reaction of arenes has been developed using 2-cyanoisothiazolidine 1,1-dioxide as an electrophilic cyanation reagent. Many different directing groups can be used in this cyanation to obtain a series of cyanation products… read more here.
Keywords: cyanation reagent; hetero arenes; cyanation hetero; cyanation ... See more keywords
Paired Electrolysis for Decarboxylative Cyanation: 4-CN-Pyridine, a Versatile Nitrile Source.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01897
Abstract: A decarboxylative cyanation of amino acids under paired electrochemical reaction conditions has been developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic reaction pathway,… read more here.
Keywords: cyanation pyridine; cyanation; paired electrolysis; decarboxylative cyanation ... See more keywords
Regioselective α-Cyanation of Unprotected Alicyclic Amines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02148
Abstract: Secondary alicyclic amines are converted to α-aminonitriles via addition of TMSCN to their corresponding imines, intermediates that are produced in situ via the oxidation of amine-derived lithium amides with simple ketone oxidants. Amines with an… read more here.
Keywords: unprotected alicyclic; cyanation; cyanation unprotected; regioselective cyanation ... See more keywords
N-Cyano-2,2'-biphenyldicarboimide as a Cyanation Reagent for Co(III)-Catalyzed C-H Cyanation of Indoles in Ionic Liquids.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00164
Abstract: A mild strategy for Co(III)-catalyzed C(sp2)-H cyanation of indoles was developed by using NCBLD as an electrophilic cyanation reagent and 1-butyl-3-acetylimidazole ditrifluoromethylsulfonimide ([BAIM]NTf2) as an environmentally friendly and recyclable solvent, and a series of 2-cyano… read more here.
Keywords: iii catalyzed; cyanation indoles; cyanation reagent; cyanation ... See more keywords
Copper-Catalyzed Enantioselective Decarboxylative Cyanation of Benzylic Acids Promoted by Hypervalent Iodine(III) Reagents.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00816
Abstract: Copper-catalyzed asymmetric radical cyanation reactions have emerged as a powerful strategy for rapid construction of α-chiral nitriles. However, the directly decarboxylative cyanation reactions of common alkyl carboxylic acids remain largely elusive. Herein, we report a… read more here.
Keywords: enantioselective decarboxylative; benzylic acids; cyanation; cyanation benzylic ... See more keywords
Carbon Dioxide-Catalyzed Stereoselective Cyanation Reaction
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DOI: 10.1021/acscatal.9b01087
Abstract: We report a Michael-type cyanation reaction of coumarins by using CO2 as a catalyst. The delivery of the nucleophilic cyanide was realized by catalytic amounts of CO2, which forms cyanoformate and ... read more here.
Keywords: dioxide catalyzed; cyanation; catalyzed stereoselective; cyanation reaction ... See more keywords