Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance.
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DOI: 10.1016/j.ejphar.2019.172611
Abstract: Multidrug resistance (MDR) leads to inadequate response to chemotherapy and cause failure in cancer treatment. One of the targeted approaches to overcome MDR in cancer cells is interfering or inhibiting ATP binding cassette (ABC) transporters.… read more here.
Keywords: transporter subfamily; mdr; abc transporter; cyano phenylpyrimidin ... See more keywords