Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation.
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DOI: 10.1172/jci.insight.129183
Abstract: Nitric oxide (NO) regulates blood pressure (BP) by binding the reduced heme iron (Fe2+) in soluble guanylyl cyclase (sGC) and relaxing vascular smooth muscle cells (SMC). We previously showed that sGC heme iron reduction (Fe3+… read more here.
Keywords: cyb5r3; smooth muscle; smc cyb5r3; sgc heme ... See more keywords