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Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113819
Abstract: The inhibition of glutaminyl cyclase (QC) may provide a promising strategy for the treatment of early Alzheimer's disease (AD) by reducing the amount of the toxic pyroform of β-amyloid (AβΝ3pE) in the brains of AD…
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Keywords:
glutaminyl cyclase;
highly potent;
potent human;
cyclase ... See more keywords
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Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.12.014
Abstract: Prokaryotic CRISPR/Cas systems confer immunity against invading nucleic acids through effector complexes. Csm1, the signature protein of Type III effector complexes, catalyses cyclic oligoadenylate synthesis when in the effector complex, but not when alone, activating…
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Keywords:
crispr cas;
dna polymerase;
polymerase;
cyclase ... See more keywords
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Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.049
Abstract: cAMP (Cyclic Adenosine monophosphate), one of the most highly studied second messengers, is regulated by a family of adenylyl cyclase (AC) enzymes. Type 3 adenylyl cyclase (abbreviated as AC3), a subtype of adenylyl cyclase, is…
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Keywords:
adenylyl cyclase;
type adenylyl;
root ganglion;
dorsal root ... See more keywords
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Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104342
Abstract: Human glutaminyl cyclase (hQC) is an important enzyme for post-translational modification by converting the N-terminal glutaminyl and glutamyl into its pyroglutamate (pGlu) through cyclization. The two isoforms of hQC, secretory glutaminyl cyclase (sQC) and golgi…
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Keywords:
glutaminyl cyclase;
function inhibitors;
alzheimer disease;
human glutaminyl ... See more keywords
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Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00509
Abstract: Fusicoccadiene synthase from the fungus Phomopsis amygdali (PaFS) is an assembly-line terpene synthase that catalyzes the first two steps in the biosynthesis of Fusiccocin A, a diterpene glycoside. The C-terminal prenyltransferase domain of PaFS catalyzes…
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Keywords:
prenyltransferase;
prenyltransferase cyclase;
cyclase;
fusicoccadiene synthase ... See more keywords
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Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00325
Abstract: Pyroglutamate (pE) modification, catalyzed mainly by glutaminyl cyclase (QC), is prevalent throughout nature and is particularly important in mammals including humans for the maturation of hormones, peptides, and proteins. In humans, the upregulation of QC…
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Keywords:
glutaminyl cyclase;
diseases development;
cyclase diseases;
cyclase ... See more keywords
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Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00751
Abstract: Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consist of various factors; thus, there is a call for alternative approaches to tackle the multifaceted…
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Keywords:
glutaminyl cyclase;
discovery conformationally;
conformationally restricted;
restricted human ... See more keywords
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Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00684
Abstract: The biosynthetic gene cluster of atlantinone B (10) was discovered in Penicillium chrysogenum MT-40. A multifunctional cytochrome P450 (AtlD) encoded by the cluster is responsible for the formation of the unique lactone-bridged ring and the…
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Keywords:
cyclase;
cytochrome p450;
atlantinone;
multifunctional cytochrome ... See more keywords
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Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00616
Abstract: Ascochlorin is a medicinally important fungal meroterpenoid. Its biosynthetic pathway in Fusarium sp. was identified, and the stereoselective epoxidation of the farnesyl group by the multidomain, soluble P450 monooxygenase AscE and the subsequent formation of…
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Keywords:
cyclase;
biosynthetic pathway;
multidomain p450;
pathway fusarium ... See more keywords
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Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28685-y
Abstract: Adenylyl cyclase 9 (AC9) is a membrane-bound enzyme that converts ATP into cAMP. The enzyme is weakly activated by forskolin, fully activated by the G protein Gαs subunit and is autoinhibited by the AC9 C-terminus.…
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Keywords:
cyclase;
mant gtp;
activation;
binding site ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14501-x
Abstract: The adenylate cyclase toxin (CyaA) of the whooping cough agent Bordetella pertussis subverts immune functions of host myeloid cells expressing the αMβ2 integrin (CD11b/CD18, CR3 or Mac-1). CyaA delivers into cytosol of cells an extremely…
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Keywords:
cyclase toxin;
camp signaling;
adenylate cyclase;
toxin ... See more keywords