Role of pituitary adenylate cyclase‐activating polypeptide in modulating hypothalamic‐pituitary system
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12094
Abstract: Pituitary adenylate cyclase‐activating polypeptide (PACAP) is a multifunctional peptide that is isolated and identified from the ovine hypothalamus, whose effects and mechanisms have been elucidated in numerous studies. The PACAP and its receptor are widely… read more here.
Keywords: activating polypeptide; cyclase activating; pituitary adenylate; adenylate cyclase ... See more keywords
Emerging evidence for the role of pituitary adenylate cyclase-activating peptide in neuropsychiatric disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.06.009
Abstract: Stress activates many brain nuclei and causes acute changes in several physiological and behavioral responses to restore homeostasis in affected organisms. While this response is protective, chronic stress exposure causes the sustained activation of these… read more here.
Keywords: cyclase activating; neuropsychiatric disorders; emerging evidence; stress ... See more keywords
Protective effects of pituitary adenylate cyclase activating polypeptide against neurotoxic agents
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.03.010
Abstract: HighlightsPACAP has very potent neuroprotective actions against different neurotoxic agents.We give a summary of the neuroprotective effects against the most commonly used neurotoxic agents, such as 6‐OHDA, MPTP, glutamate and some less well‐known neurotoxic compounds.… read more here.
Keywords: cyclase activating; neuroprotective effects; neurotoxic agents; pituitary adenylate ... See more keywords
Multiple nickel‐sensitive targets elicit cardiac arrhythmia in isolated mouse hearts after pituitary adenylate cyclase‐activating polypeptide‐mediated chronotropy
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2016.12.025
Abstract: Graphical abstract Figure. No Caption available. Abstract The pituitary adenylate cyclase‐activating polypeptide (PACAP)‐27 modulates various biological processes, from the cellular level to function specification. However, the cardiac actions of this neuropeptide are still under intense… read more here.
Keywords: cyclase activating; bpm; pacap; pituitary adenylate ... See more keywords
Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina
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DOI: 10.1038/s41598-018-20893-1
Abstract: Retinal guanylate cyclase (RetGC) and guanylate cyclase activating proteins (GCAPs) play an important role during the light response in photoreceptor cells. Mutations in these proteins are linked to distinct forms of blindness. RetGC and GCAPs… read more here.
Keywords: cyclase activating; photoreceptor cells; guanylate cyclase; retgc ... See more keywords
Pituitary adenylate cyclase‐activating peptide: Potential roles in the pathophysiology and complications of cirrhosis
Sign Up to like & getrecommendations! Published in 2020 at "Liver International"
DOI: 10.1111/liv.14602
Abstract: Pituitary adenylate cyclase‐activating peptide (PACAP) is a ubiquitous neuropeptide with diverse functions throughout the organism. Most abundantly investigated for its role in several neurological disorders as well as in circadian rhythms, other fields of medicine,… read more here.
Keywords: cyclase activating; activating peptide; cirrhosis; pituitary adenylate ... See more keywords
Pituitary Adenylate Cyclase Activating Polypeptide Elicits Neuroprotection Against Acute Ischemic Neuronal Cell Death Associated with NMDA Receptors
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000495722
Abstract: Background/Aims: The endogenous neurotrophic peptides pituitary adenylate cyclase-activating polypeptides (PACAP-27/38) protect against stroke, but the molecular mechanism remains unknown. Methods: Primary rat neural cells were exposed to PACAP-27 or PACAP-38 before induction of experimental acute… read more here.
Keywords: cyclase activating; pacap; pituitary adenylate; adenylate cyclase ... See more keywords
The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0260-22.2022
Abstract: Abstract Many psychiatric diseases stem from an inability to cope with stressful events, as chronic stressors can precipitate or exacerbate psychopathologies. The neurobiological mechanisms underlying the response to chronic stress and the resulting anxiety states… read more here.
Keywords: system; stress; pituitary adenylate; adenylate cyclase ... See more keywords
Pituitary Adenylate Cyclase-Activating Polypeptide in Learning and Memory
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.663418
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved neuropeptide that regulates neuronal physiology and transcription through Gs/Gq-coupled receptors. Its actions within hypothalamic, limbic, and mnemonic systems underlie its roles in stress regulation, affective processing,… read more here.
Keywords: cyclase activating; pacap; pituitary adenylate; adenylate cyclase ... See more keywords
Pituitary Adenylate Cyclase Activating Peptide and Post-traumatic Stress Disorder: From Bench to Bedside
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.861606
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with isoforms consisting of either 27 or 38 amino acids. PACAP is encoded by the adenylate cyclase activating peptide gene, ADCYAP1, in humans and the highly conserved… read more here.
Keywords: activating peptide; cyclase activating; pituitary adenylate; adenylate cyclase ... See more keywords
Presence of Systemic Amyloidosis in Mice with Partial Deficiency in Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Aging
Sign Up to like & getrecommendations! Published in 2021 at "Applied Sciences"
DOI: 10.3390/app11167373
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with widespread expression and general cytoprotective effects, is also involved in aging. Previously, we observed accelerated systemic senile amyloidosis in PACAP knockout (KO) mice. As mice partially lacking… read more here.
Keywords: cyclase activating; pacap; pituitary adenylate; adenylate cyclase ... See more keywords