Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells
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DOI: 10.1038/s41598-017-14501-x
Abstract: The adenylate cyclase toxin (CyaA) of the whooping cough agent Bordetella pertussis subverts immune functions of host myeloid cells expressing the αMβ2 integrin (CD11b/CD18, CR3 or Mac-1). CyaA delivers into cytosol of cells an extremely… read more here.
Keywords: cyclase toxin; camp signaling; adenylate cyclase; toxin ... See more keywords
Stability, structural and functional properties of a monomeric, calcium–loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis
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DOI: 10.1038/srep42065
Abstract: Bordetella pertussis, the causative agent of whooping cough, secretes an adenylate cyclase toxin, CyaA, which invades eukaryotic cells and alters their physiology by cAMP overproduction. Calcium is an essential cofactor of CyaA, as it is… read more here.
Keywords: cyclase toxin; bordetella pertussis; adenylate cyclase; calcium ... See more keywords
Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis
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DOI: 10.1128/mbio.01527-22
Abstract: Despite high vaccine coverage in developed countries, the incidence of pertussis has increased in recent decades, often leading to severe consequences for sensitive groups, including infants. For this reason, improving the efficacy of pertussis vaccines… read more here.
Keywords: protection; adenylate cyclase; bordetella; act ... See more keywords
Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin
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DOI: 10.1371/journal.pone.0228606
Abstract: Bordetella pertussis, the causative agent of whopping cough, produces an adenylate cyclase toxin (CyaA) that plays a key role in the host colonization by targeting innate immune cells which express CD11b/CD18, the cellular receptor of… read more here.
Keywords: cyclase toxin; bordetella pertussis; adenylate cyclase; toxin ... See more keywords
Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes
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DOI: 10.1371/journal.ppat.1009920
Abstract: RTX leukotoxins are a diverse family of prokaryotic virulence factors that are secreted by the type 1 secretion system (T1SS) and target leukocytes to subvert host defenses. T1SS substrates all contain a C-terminal RTX domain… read more here.
Keywords: cyclase toxin; antibody; adenylate cyclase; rtx ... See more keywords
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes
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DOI: 10.3390/toxins13020083
Abstract: The adenylate cyclase toxin, CyaA, is one of the key virulent factors produced by Bordetella pertussis, the causative agent of whooping cough. This toxin primarily targets innate immunity to facilitate bacterial colonization of the respiratory… read more here.
Keywords: cyclase toxin; bordetella pertussis; adenylate cyclase; biotechnological purposes ... See more keywords