Suppression of Lung Cancer Malignancy by Micellized siRNA through Cell Cycle Arrest
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202358
Abstract: UBA6‐specific E2 conjugation enzyme 1 (USE1) is frequently overexpressed in lung cancer patients. Moreover, the critical role of USE1 in the progression of human lung cancer is also indicated. As the next step, the authors… read more here.
Keywords: cycle arrest; lung cancer; cell cycle; cancer ... See more keywords
LncRNA UCA1 Antagonizes Arsenic‐Induced Cell Cycle Arrest through Destabilizing EZH2 and Facilitating NFATc2 Expression
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201903630
Abstract: Abstract Arsenic (As) is a widespread metalloid contaminant, and its internal exposure is demonstrated to cause serious detrimental health problems. Albeit considerable studies are performed to interrogate the molecular mechanisms responsible for As‐induced toxicities, the… read more here.
Keywords: cycle arrest; induced cell; cell cycle; ezh2 ... See more keywords
W436, a novel SMART derivative, exhibits anti‐hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22831
Abstract: Hepatocellular carcinoma (HCC) is considered one of the most common primary liver cancers and the second leading cause of cancer‐associated mortality around the world annually. Therefore, it is urgent to develop novel drugs for HCC… read more here.
Keywords: cycle arrest; hcc cells; cell cycle; w436 ... See more keywords
Cell cycle arrest and gene expression profiling of testis in mice exposed to fluoride
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22377
Abstract: Exposure to fluoride results in low reproductive capacity; however, the mechanism underlying the impact of fluoride on male productive system still remains obscure. To assess the potential toxicity in testis of mice administrated with fluoride,… read more here.
Keywords: cycle arrest; testis; cell cycle; gene expression ... See more keywords
Cell cycle arrest and induction of apoptosis of newly synthesized pyranoquinoline derivatives under microwave irradiation
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02325-5
Abstract: A set of 2-amino-4-aryl-4H-pyrano[3,2-h]quinoline-3-carbonitrile derivatives were prepared via a one-pot, three-component condensation reaction between the substituted hydroxyquinoline derivatives, some aryl and/or hetaryl aldehydes, and malononitrile in an ethanol/piperidine solution in a microwave irradiation environment. The… read more here.
Keywords: cycle arrest; cell; microwave irradiation; cell cycle ... See more keywords
In vitro anticancer activity of pyrano[3, 2-c]chromene derivatives with both cell cycle arrest and apoptosis induction
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02494-3
Abstract: A series of 2-amino-4-aryl-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4a–m) were synthesized via a one-pot three component condensation reaction between 4-hydroxy-2H-chromen-2-one, various aryl aldehydes and malononitrile in the presence of piperidine as a catalyst in ethanol under microwave irradiation conditions,… read more here.
Keywords: cancer; activity; cell cycle; cycle arrest ... See more keywords
Repurposed antipsychotic chlorpromazine inhibits colorectal cancer and pulmonary metastasis by inducing G2/M cell cycle arrest, apoptosis, and autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04386-z
Abstract: Despite efforts in developing effective therapeutic strategies, colorectal cancer (CRC) remains one of the most prevalent and lethal neoplasms. Repurposing approved drugs is an alluring strategy for developing anticancer agents. Some antipsychotic drugs, including chlorpromazine… read more here.
Keywords: cancer; metastasis; cell cycle; cycle arrest ... See more keywords
Kinetics of the cell cycle arrest biomarkers (TIMP-2*IGFBP-7) for prediction of acute kidney injury in infants after cardiac surgery
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Nephrology"
DOI: 10.1007/s00467-017-3655-y
Abstract: BackgroundTissue inhibitor metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein-7 (IGFBP-7) are cell-cycle arrest biomarkers that have been shown to be predictive of acute kidney injury (AKI) in critically ill adults. AKI affects a large… read more here.
Keywords: cycle arrest; cell cycle; timp igfbp; cardiac surgery ... See more keywords
Oxidative stress and cell cycle arrest induced by short-term exposure to dustfall PM2.5 in A549 cells
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-0430-3
Abstract: It was reported that in vitro short-term exposure to PM2.5 caused different lung diseases through inflammatory response, immune toxicity, oxidative stress, and genetic mutations. However, the complex molecular biological mechanism for its toxicity had not… read more here.
Keywords: a549 cells; arrest; cell cycle; cycle arrest ... See more keywords
Knockdown of GRHL3 inhibits activities and induces cell cycle arrest and apoptosis of human colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Current Medical Science"
DOI: 10.1007/s11596-017-1821-x
Abstract: SummaryThe Grainyhead-like 3 (GRHL3) is involved in epidermal barrier formation, neural tube closure and wound repair. Previous studies have suggested that GRHL3 has been linked to many different types of cancers. However, to date, its… read more here.
Keywords: cycle arrest; cell cycle; grhl3; crc ... See more keywords
A specific inhibitor of polo-like kinase 1, GSK461364A, suppresses proliferation of Raji Burkitt's lymphoma cells through mediating cell cycle arrest, DNA damage, and apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109288
Abstract: Polo-like kinase 1 (PLK1) is a prominent mediatory player during the cell cycle, mitosis, and cytokinesis in eukaryotic cells. Besides its physiological roles, PLK1 expression is upregulated in a wide range of human malignant tumors… read more here.
Keywords: raji; cycle arrest; gsk461364a; cell cycle ... See more keywords