A Selective Nano Cell Cycle Checkpoint Inhibitor Overcomes Leukemia Chemoresistance.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202300736
Abstract: Cell cycle checkpoint activation promotes DNA damage repair, which is highly associated with the chemoresistance of various cancers including acute myeloid leukemia (AML). Selective cell cycle checkpoint inhibitors are strongly demanded to overcome chemoresistance, but… read more here.
Keywords: chemoresistance; checkpoint; cell cycle; cycle checkpoint ... See more keywords
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aba7401
Abstract: The CHK1/2 inhibitor LY2606368 (prexasertib) sensitizes high-risk medulloblastoma to chemotherapy and improves survival in multiple in vivo models. Combined treatment for medulloblastoma Certain subtypes of medulloblastoma (MB) have poor treatment outcome. To identify better treatments,… read more here.
Keywords: cycle checkpoint; treatment; cell; cell cycle ... See more keywords
Cell cycle checkpoint defects in gastrointestinal malignancies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.680
Abstract: 680Background: Cyclin Dependent Kinases (CDKs) play a significant role in cell cycle regulation. Aberrations involving the cell cycle pathway genes can lead to uncontrolled cell proliferation and genomic instability. These could potentially be targeted with… read more here.
Keywords: cycle checkpoint; cell cycle; cycle; defects gastrointestinal ... See more keywords