Cycle threshold values and SARS‐CoV‐2: Relationship to demographic characteristics and disease severity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27752
Abstract: Cycle threshold (Ct), or the number of cycles required to amplify viral RNA to a detectable level, provides an estimate of viral load. Previous studies have demonstrated mixed results in regard to the association between… read more here.
Keywords: relationship; sars cov; cycle threshold; demographic characteristics ... See more keywords
The interdependence between rhinovirus cycle threshold values, viral co‐detections, and clinical disease severity in children with and without comorbidities
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29833
Abstract: Rhinoviruses (RVs) are a leading cause of acute respiratory infections (ARI) in children. The relationship between RV viral loads (VL), RV/viral‐co‐detections and disease severity, is incompletely understood. We studied children and adolescents ≤21 years with… read more here.
Keywords: disease severity; cycle threshold; viral detections; threshold values ... See more keywords
Factors associated with cycle threshold values (Ct-values) of SARS-CoV2-rRT-PCR
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology Reports"
DOI: 10.1007/s11033-022-07360-x
Abstract: Background Presented work studies the association of COVID-19 severity, patient demographics, and clinical history with cycle threshold (Ct) values of SARS CoV2-rRT-PCR. We studied the Ct values for Orf1ab, N, and RdRp genes in association… read more here.
Keywords: threshold values; sars cov2; values sars; pcr ... See more keywords
Cycle threshold responses in SARS-COV2 PCR tests depend on the method by which the samples were obtained and require strict global standardization
Sign Up to like & getrecommendations! Published in 2022 at "Infection"
DOI: 10.1007/s15010-022-01772-4
Abstract: Since 2020, a SARS-COV2 epidemic has been raging worldwide. The cycle of the PCR test in which the virus is detected is called cycle threshold (CT). The method of obtaining the sample is not detailed… read more here.
Keywords: sample; sars cov2; cycle; method ... See more keywords
A Narrative Systematic Review of the Clinical Utility of Cycle Threshold Values in the Context of COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-020-00324-3
Abstract: The ability to predict likely prognosis and infectiousness for patients with COVID-19 would aid patient management decisions. Diagnosis is usually via real-time PCR, and it is unclear whether the semi-quantitative capability of this method, determining… read more here.
Keywords: correlation; threshold values; value; cycle threshold ... See more keywords
Caution in interpretation of SARS-CoV-2 quantification based on RT-PCR cycle threshold value
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostic Microbiology and Infectious Disease"
DOI: 10.1016/j.diagmicrobio.2021.115366
Abstract: RT-PCR is the reference method for diagnosis of a Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection. During the setting up of 6 SARS-CoV-2 RT-PCR assays in our laboratory, comparative evaluations were systematically undertaken and allowed to… read more here.
Keywords: cycle threshold; cov quantification; interpretation sars; sars cov ... See more keywords
[Application of the PCR number of cycle threshold value (Ct) in COVID-19].
Sign Up to like & getrecommendations! Published in 2021 at "Semergen"
DOI: 10.1016/j.semerg.2021.05.003
Abstract: The SARS-CoV-2 pandemic persists with all its virulence despite 650,382,819 doses of COVID vaccine worldwide. The reference test for infection identification is reverse transcription polymerase chain reaction (RT-qPCR). The usefulness of this test may be… read more here.
Keywords: cycle threshold; number cycle; number; threshold value ... See more keywords
Challenges associated with using cycle threshold (Ct) value of reverse-transcription polymerase chain reaction (RT-PCR) as a criteria for infectiousness of coronavirus disease 2019 (COVID-19) patients in India
Sign Up to like & getrecommendations! Published in 2021 at "Infection Control and Hospital Epidemiology"
DOI: 10.1017/ice.2021.357
Abstract: To the Editor—We read with great interest the article “COVID-19 Admission Screening, and Assessment of Infectiousness at an Academic Medical Center, Iowa 2020” by Alsuhaibani et al,1 in which the cycle threshold (Ct) value of… read more here.
Keywords: cycle threshold; value; pcr; epidemiology ... See more keywords
Cycle threshold of SARS-CoV-2 RT-PCR as a driver of retesting
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DOI: 10.1038/s41598-024-52984-7
Abstract: SARS-CoV-2 RT-PCR is a critical and, at times, limited resource. Frequent Retesting of patients may strain testing infrastructure unduly. Recommendations that include cycle threshold (Ct) cutoffs may incentivize early retesting when the Ct value is… read more here.
Keywords: sars cov; cov pcr; cycle threshold; pcr driver ... See more keywords
Can Use of Viral Load Improve Norovirus Clinical Diagnosis and Disease Attribution?
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DOI: 10.1093/ofid/ofx131
Abstract: Background Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) is the state-of-the-art diagnostic for norovirus. Cycle threshold (Ct), an indicator of viral load, may be associated with symptomatic disease as well as demographic and outbreak characteristics. Methods… read more here.
Keywords: threshold values; viral load; disease; cycle threshold ... See more keywords
Considerations regarding Interpretation of Positive SARS-CoV-2 Molecular Results with Late Cycle Threshold Values
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.00501-22
Abstract: COVID-19 disease lies on a spectrum, ranging from completely asymptomatic to mild disease to severe and critical disease. Studies have shown that prolonged shedding or sporadic detection of SARS-CoV-2 RNA can occur long after symptom… read more here.
Keywords: threshold values; disease; interpretation; late cycle ... See more keywords