Synthesis of new symmetric cyclic and acyclic halocurcumin analogues typical precursors for hybridization
Sign Up to like & getrecommendations! Published in 2020 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-020-04264-y
Abstract: It is believed that the synthesis of hybrid molecules containing different biologically relevant moieties would furnish multifunctional drugs with the possible synergism of potential importance for the treatment of cancer, diabetic and Alzheimer diseases. It… read more here.
Keywords: halocurcumin analogues; acyclic halocurcumin; precursors hybridization; typical precursors ... See more keywords
Synthesis of Dideoxy-octonic Acid and Cyclic and Acyclic Derivatives Thereof.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00842
Abstract: Oxidative cleavage of N-acetyl-neuraminic acid (Neu5Ac, 1) leads to the open chain octonic acid (ADOA, 2), which under various conditions is transformed into an acyclic acid or ester or into a six- or five-membered octonic… read more here.
Keywords: octonic acid; dideoxy octonic; synthesis dideoxy; acid cyclic ... See more keywords
Tuning the Reactivity of Ketones through Unsaturation: Construction of Cyclic and Acyclic Quaternary Stereocenters via Zn-ProPhenol Catalyzed Mannich Reactions
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DOI: 10.1021/acscatal.8b04685
Abstract: Introduction of unsaturation adjacent to the carbonyl drastically improves the reactivity of the Zn-ProPhenol catalyzed Mannich reactions between N-carbamoyl imines and a-branched ketones. Despite only a small change in the substrate acidity, the bimetallic catalyst… read more here.
Keywords: cyclic acyclic; acyclic quaternary; catalyzed mannich; quaternary stereocenters ... See more keywords
Copper-Catalyzed Cleavage of Unstrained C–C Bonds for the Synthesis of 1-Acyloxy-2,2,6,6-tetramethylpiperidines from Cyclic or Acyclic Ketones
Sign Up to like & getrecommendations! Published in 2017 at "Synlett"
DOI: 10.1055/s-0036-1590805
Abstract: A copper-catalyzed approach for the synthesis of 1-acyloxy-2,2,6,6-tetramethylpiperidines through the C–C bond cleavage of cyclic or acyclic ketones was developed. In this chemistry, a combination of CuCl2·2H2O, 1,10-phenanthroline monohydrate, and aniline was crucial for the… read more here.
Keywords: acyclic ketones; acyloxy tetramethylpiperidines; cyclic acyclic; synthesis acyloxy ... See more keywords