Cyclic acyl amidines as unexpected C4-donors for fully substituted pyridine ring formation in the base mediated reaction with malononitrile
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.06.038
Abstract: Abstract A new one-step, pseudo four-component approach for the synthesis of fully substituted pyridines via ring-opening of the cyclic acyl amidine of 3-amino-1 H -isoindol-1-one and its aza-analogues during the reaction with malononitrile in the… read more here.
Keywords: pyridine ring; cyclic acyl; reaction; reaction malononitrile ... See more keywords
Experimental and Computational Studies Unraveling the Peculiarity of Enolizable Oxoesters in the Organocatalyzed Mannich-Type Addition to Cyclic N-Acyl Iminium Ions
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DOI: 10.3390/molecules25081903
Abstract: γ− and δ-Oxoesters are easily available starting materials that have been sparingly used in some organocatalyzed reactions proceeding with a high enantioselectivity. In our experimentation we found that the use of these compounds as the… read more here.
Keywords: organocatalyzed mannich; iminium ions; mannich type; cyclic acyl ... See more keywords
Synthesis of Cyclic N-Acyl Amidines by [3 + 2] Cycloaddition of N-Silyl Enamines and Activated Acyl Azides
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DOI: 10.3390/molecules27051696
Abstract: In this study, we describe the synthesis of cyclic N-acyl amidines from readily available N-heteroarenes. The synthetic methodology utilized the versatile N-silyl enamine intermediates from the hydrosilylation of N-heteroarenes for the [3 + 2] cycloaddition… read more here.
Keywords: acyl azides; acyl amidines; methodology; synthesis cyclic ... See more keywords