Anti‐hypertensive mechanisms of cyclic depsipeptide inhibitor ligands for Gq/11 class G proteins
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2019.01.012
Abstract: &NA; Augmented vasoconstriction is a hallmark of hypertension and is mediated partly by hyper‐stimulation of G protein couple receptors (GPCRs) and downstream signaling components. Although GPCR blockade is a key component of current anti‐hypertensive strategies,… read more here.
Keywords: hypertensive mechanisms; cyclic depsipeptide; anti hypertensive; depsipeptide inhibitor ... See more keywords
Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01172
Abstract: Genome mining and bioinformatics analyses allowed us to rationally find a candidate biosynthetic gene cluster for a new cyclic depsipeptide of Chaetomium mollipilium. A heterologous reconstitution of the identified biosynthetic pathway predictably afforded a new… read more here.
Keywords: genome mining; cyclic depsipeptide; chaetomium mollipilium; depsipeptide ... See more keywords
Benderamide A, a Cyclic Depsipeptide from a Singapore Collection of Marine Cyanobacterium cf. Lyngbya sp.
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DOI: 10.3390/md16110409
Abstract: Benderamide A (1), a (S)-2,2-dimethyl-3-hydroxy-7-octynoic acid (S-Dhoya)-containing cyclic depsipeptide that belongs to the kulolide superfamily, was isolated from a Singapore collection of cf. Lyngbya sp. marine cyanobacterium using a bioassay-guided approach. While the planar structure… read more here.
Keywords: marine; cyclic depsipeptide; marine cyanobacterium; singapore collection ... See more keywords