Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.023
Abstract: G proteins are key mediators in the signaling of G protein-coupled receptors and involved in a plethora of important physiological processes. The natural product cyclic depsipeptides YM-254890 and FR900359 are the only known selective inhibitors… read more here.
Keywords: 254890 fr900359; depsipeptides 254890; cyclic depsipeptides; natural product ... See more keywords
Skyllamycins D and E, Non-Ribosomal Cyclic Depsipeptides from Lichen-Sourced Streptomyces anulatus.
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DOI: 10.1021/acs.jnatprod.1c00547
Abstract: The skyllamycins are a class of heavily modified, non-ribosomal peptides, first isolated from Streptomyces sp. KY11784. A Streptomyces strain with potent antibiotic activity against Bacillus subtilis was isolated from a sample of the New Zealand… read more here.
Keywords: lichen sourced; cyclic depsipeptides; non ribosomal; depsipeptides lichen ... See more keywords
Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.7b00034
Abstract: A family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A-D (1-4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens using bioassay-guided and spectroscopic approaches. The planar structures of… read more here.
Keywords: cyanobacterium moorea; dudawalamides antiparasitic; moorea producens; cyclic depsipeptides ... See more keywords