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Cyclic Dichalcogenides Extend the Reach of Bioreductive Prodrugs to Harness Thiol/Disulfide Oxidoreductases: Applications to seco-Duocarmycins Targeting the Thioredoxin System

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2 Published in 2023 at "ACS Central Science"

DOI: 10.1021/acscentsci.2c01465

Abstract: Small-molecule prodrug approaches that can activate cancer therapeutics selectively in tumors are urgently needed. Here, we developed the first antitumor prodrugs designed for activation by thiol-manifold oxidoreductases, targeting the thioredoxin (Trx) system. The Trx system… read more here.

Keywords: thiol; system; cyclic dichalcogenides; bioreductive prodrugs ... See more keywords