CuH-Catalyzed Enantioselective Desymmetrization of Cyclic 1,3-Diketones.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03359
Abstract: Herein, we report a CuH-catalyzed asymmetric desymmetrization of prochiral cyclopentane-1,3-diones to access cyclic 3-hydroxy ketones having an all-carbon quaternary center with high diastereoselectivity via hydrosilylation using PMHS as an inexpensive hydride source. This reaction displays… read more here.
Keywords: cuh catalyzed; desymmetrization cyclic; desymmetrization; enantioselective desymmetrization ... See more keywords
Mannich-type addition of cyclic 1,3-diketones to N-acyliminium ions: Access to aza-sugars.
Sign Up to like & getrecommendations! Published in 2023 at "Carbohydrate research"
DOI: 10.2139/ssrn.4311169
Abstract: A novel three-component strategy has been developed for the synthesis of iminosugars in good to excellent yields. This is the first report on the Mannich type addition of cyclic 1,3-diketones to aza-acetal derived from hydroxy-γ-lactone… read more here.
Keywords: aza sugars; type addition; mannich type; addition cyclic ... See more keywords
Desymmetrization of Cyclic 1,3-Diketones under N-Heterocyclic Carbene Organocatalysis: Access to Organofluorines with Multiple Stereogenic Centers
Sign Up to like & getrecommendations! Published in 2021 at "Research"
DOI: 10.34133/2021/9867915
Abstract: Symmetric 1,3-diketones with fluorine or fluorinated substituents on the prochiral carbon remain to be established. Herein, we have developed a novel prochiral fluorinated oxindanyl 1,3-diketone and successfully applied these substrates in carbene-catalyzed asymmetric desymmetrization. Accordingly,… read more here.
Keywords: desymmetrization cyclic; cyclic diketones; diketones heterocyclic; multiple stereogenic ... See more keywords