Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cthGAMP
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200005
Abstract: The cGAS‐STING pathway is known for its role in sensing cytosolic DNA introduced by a viral infection, bacterial invasion or tumorigenesis. Free DNA is recognized by the cyclic GMP‐AMP synthase (cGAS) catalyzing the production of… read more here.
Keywords: cyclic dinucleotides; dinucleotides cthgamp; chemical synthesis; fluorescent cyclic ... See more keywords
Synthesis of All Possible Canonical (3'-5'-Linked) Cyclic Dinucleotides and Evaluation of Riboswitch Interactions and Immune-Stimulatory Effects.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b06141
Abstract: The cyclic dinucleotides (CDNs) c-di-GMP, c-di-AMP, and c-AMP-GMP are widely utilized as second messengers in bacteria, where they signal lifestyle changes such as motility and biofilm formation, cell wall and membrane homeostasis, virulence, and exo-electrogenesis.… read more here.
Keywords: cyclic dinucleotides; immune stimulatory; synthesis possible; possible canonical ... See more keywords
Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
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DOI: 10.1080/20002297.2018.1538927
Abstract: ABSTRACT Background: Cyclic dinucleotides (cyclic di-guanosine monophosphate (c-di-GMP) and cyclic di-adenosine monophosphate (c-di-AMP)) and lipopolysaccharides (LPS) are pathogen-associated molecular patterns (PAMPs). Individual impacts of PAMPs on immune system have been evaluated, but simultaneous actions of… read more here.
Keywords: cyclic dinucleotides; cytokine response; epithelial cytokine; gingival epithelial ... See more keywords
SLC19A1 Transports STING-Stimulating Cyclic Dinucleotides into Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-145
Abstract: The folate transporter SLC19A1 ferries charged cyclic dinucleotides (CDN) into human cells. read more here.
Keywords: sting stimulating; dinucleotides cells; cyclic dinucleotides; slc19a1 transports ... See more keywords