The opposite effect of K+ and Na+ on the hydrolysis of linear and cyclic dipeptides
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.04.073
Abstract: Potassium and sodium are generally considered inert ‘spectator’ ions for organic reactions. Here, we report rate constants for the acid-promoted hydrolysis of the seven dipeptides of glycine (G) and alanine (A) and an unexpected pattern… read more here.
Keywords: cyclic dipeptides; opposite effect; presence; hydrolysis linear ... See more keywords
Bacterial Lipodepsipeptides and Some of Their Derivatives and Cyclic Dipeptides as Potential Agents for Biocontrol of Pathogenic Bacteria and Fungi of Agrarian Plants
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.1c08139
Abstract: Biotic stresses (fungi, bacteria, insects, weeds, etc.) are some of the most important causes of the decrease in the quality and quantity of crops that could become an emergency due to a noteworthy increase in… read more here.
Keywords: agrarian plants; pathogenic bacteria; bacterial lipodepsipeptides; bacteria fungi ... See more keywords
Bioactivatable pseudo-tripeptidization of cyclic dipeptides to increase the affinity toward oligopeptide transporter 1 for enhanced oral absorption: an application to cyclo(L-Hyp-L-Ser) (JBP485).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00358
Abstract: The cyclic dipeptides generally present lower affinity toward intestinal oligopeptide transporter 1 (PEPT1) than the linear dipeptides. JBP485 (cyclo(L-Hyp-L-Ser)) is a low-affinity substrate of PEPT1 with poor oral bioavailability. However, JBP923 (L-Hyp-L-Ser) is a high-affinity… read more here.
Keywords: cyclic dipeptides; affinity; hyp ser; pseudo tripeptidization ... See more keywords
Hydrophobic cyclic dipeptides as M+/Cl- carriers.
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DOI: 10.1039/d3cc02132g
Abstract: Transmembrane ion-pair co-transport using synthetic transporters is non-trivial. Herein, cyclic dipeptide ion-carriers with dangling ester motifs to bind cations and amide-NH to bind anions are reported. The pendant lipophilic norbornene units aid in membrane insertion… read more here.
Keywords: cyclic dipeptides; hydrophobic cyclic; dipeptides carriers;
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides
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DOI: 10.3390/md20020085
Abstract: Quorum sensing (QS) can regulate the pathogenicity of bacteria and the production of some virulence factors. It is a promising target for screening to find anti-virulence agents in the coming post-antibiotics era. Cyclo (L-Trp-L-Ser), one… read more here.
Keywords: anti activity; trp ser; activity; cyclo trp ... See more keywords