Cis/trans isomerization of proline peptide bonds in the backbone of cyclic disulfide‐bridged peptides
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DOI: 10.1002/pep2.24088
Abstract: Peptides are of interest as potential therapeutic agents, including cyclic disulfide‐bridged peptides because of their limited conformational flexibility and enhanced stability toward proteolysis. To further constrain the flexibility of the peptide backbone, the disulfide‐bridged rings… read more here.
Keywords: cys; peptide bonds; proline peptide; cis trans ... See more keywords
An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides
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DOI: 10.1039/d0gc01366h
Abstract: Macrocyclic, disulfide-rich peptides have found widespread applications in drug design and development. Current peptide production strategies rely heavily on solid phase peptide synthesis (SPPS) requiring large amounts of hazardous/toxic reagents and solvents which have negative… read more here.
Keywords: production; disulfide rich; production cyclic; rich peptides ... See more keywords