Comparative life cycle assessment of chemical and biocatalytic 2'3'-cyclic GMP-AMP synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "ChemSusChem"
DOI: 10.1002/cssc.202201629
Abstract: Life cycle assessments (LCAs) can provide insights into the environmental impact of production processes. In this study, a comparative LCA was performed for the synthesis of 2'3'-cyclic GMP-AMP (2'3'-cGAMP) in an early development stage. The… read more here.
Keywords: gmp amp; cyclic gmp; synthesis; life cycle ... See more keywords
Second Messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP):Synthesis, transmission, and degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.114934
Abstract: Cyclic GMP-AMP synthase (cGAS) senses foreign DNA to produce 2'3'-cyclic GMP-AMP (2'3'-cGAMP). 2'3'-cGAMP is a second messenger that binds and activates the adaptor protein STING, which triggers the innate immune response. As a STING agonist,… read more here.
Keywords: cgamp; amp cgamp; gmp amp; cyclic gmp ... See more keywords
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.015
Abstract: Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a predominant DNA sensor inducing the activation of the innate immune responses that produce proinflammatory cytokines and type I interferons, which has been well-investigated in mammals. However, chicken cGAS… read more here.
Keywords: gmp amp; dna; chcgas; immune responses ... See more keywords
The ever-expanding world of bacterial cyclic oligonucleotide second messengers.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2021.01.017
Abstract: Cyclic dinucleotide (cdN) second messengers are essential for bacteria to sense and adapt to their environment. These signals were first discovered with the identification of 3'-5', 3'-5' cyclic di-GMP (c-di-GMP) in 1987, a second messenger… read more here.
Keywords: ever expanding; gmp amp; expanding world; gmp ... See more keywords
Cyclic di-GMP in Streptomycetes: A New Conformation, New Binding Mode, New Receptor, and a New Mechanism to Control Cell Development.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.01.018
Abstract: A recent paper by Gallagher et al. (2020) demonstrates that c-di-GMP controls spore formation in Streptomyces venezuelae through sequestering the sporulation sigma factor σWhiG and presents the crystal structure of a ternary complex between c-di-GMP, σWhiG,… read more here.
Keywords: gmp streptomycetes; gmp; cyclic gmp; streptomycetes new ... See more keywords
In Vivo Biochemistry: Single-Cell Dynamics of Cyclic Di-GMP in Escherichia coli in Response to Zinc Overload.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00696
Abstract: Intracellular signaling enzymes drive critical changes in cellular physiology and gene expression, but their endogenous activities in vivo remain highly challenging to study in real time and for individual cells. Here we show that flow… read more here.
Keywords: biochemistry; single cell; response; zinc ... See more keywords
NosP modulates cyclic-di-GMP signaling in Legionella pneumophila.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00618
Abstract: Biofilms form when bacteria adhere to a surface and secrete an extracellular polymeric substance. Bacteria embedded within a biofilm benefit from increased resistance to antibiotics, host immune responses, and harsh environmental factors. Nitric oxide (NO)… read more here.
Keywords: nosp modulates; gmp; pneumophila; gmp signaling ... See more keywords
Protein kinase enzymes in the human vagina—relation to key mediators of the cyclic AMP and cyclic GMP pathways
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Impotence Research"
DOI: 10.1038/ijir.2017.8
Abstract: Aside from phosphodiesterase (PDE) isoenzymes, protein kinases (cAK=cyclic AMP-binding protein kinase, cGK=cyclic GMP-binding protein kinase) have also been identified as important receptors for cyclic nucleotides. A significance of protein kinases in the control of the… read more here.
Keywords: cyclic amp; cak; relation; cyclic gmp ... See more keywords
Cyclic di-GMP regulates Mycobacterium tuberculosis resistance to ethionamide
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06289-7
Abstract: Tuberculosis is still on the top of infectious diseases list on both mobility and mortality, especially due to drug-resistance of Mycobacterium tuberculosis (M.tb). Ethionamide (ETH) is one of effective second line anti-TB drugs, a synthetic… read more here.
Keywords: tuberculosis; cyclic gmp; resistance; ethr ... See more keywords
Nitric oxide dependent signaling via cyclic GMP in dendritic cells regulates migration and T-cell polarization
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29287-9
Abstract: Allergic airway inflammation is accompanied by excessive generation of nitric oxide (NO). Beside its detrimental activity due to the generation of reactive nitrogen species, NO was found to modulate immune responses by activating the NO-sensitive… read more here.
Keywords: camp; oxide dependent; cyclic gmp; signaling via ... See more keywords
Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04860f
Abstract: Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and… read more here.
Keywords: sting cyclic; cyclic gmp; targeting sting; cancer vaccines ... See more keywords