β-Branched Amino Acids Stabilize Specific Conformations of Cyclic Hexapeptides.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.12.015
Abstract: Cyclic peptides (CPs) are a promising class of molecules for drug development, particularly as inhibitors of protein-protein interactions. Predicting low-energy structures and global structural ensembles of individual CPs is critical for the design of bioactive… read more here.
Keywords: cyclic hexapeptides; amino acids; well structured; global structural ... See more keywords
Genomics-Driven Discovery of Chlorinated Cyclic Hexapeptides Ulleungmycins A and B from a Streptomyces Species.
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DOI: 10.1021/acs.jnatprod.7b00660
Abstract: Analysis of the genome sequence of Streptomyces sp. KCB13F003 showed the presence of a cryptic gene cluster encoding flavin-dependent halogenase and nonribosomal peptide synthetase. Pleiotropic approaches using multiple culture media followed by LC-MS-guided isolation and… read more here.
Keywords: cyclic hexapeptides; driven discovery; hexapeptides ulleungmycins; discovery chlorinated ... See more keywords
Bistratamides M and N, Oxazole-Thiazole Containing Cyclic Hexapeptides Isolated from Lissoclinum bistratum Interaction of Zinc (II) with Bistratamide K
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DOI: 10.3390/md15070209
Abstract: Two novel oxazole-thiazole containing cyclic hexapeptides, bistratamides M (1) and N (2) have been isolated from the marine ascidian Lissoclinum bistratum (L. bistratum) collected in Raja Ampat (Papua Bar, Indonesia). The planar structure of 1… read more here.
Keywords: cyclic hexapeptides; bistratum; containing cyclic; lissoclinum bistratum ... See more keywords