Synthesis of 4-substituted 3-(2-hydroxyphenyl)-quinolines through an unexpected iron(III) chloride promoted reaction of cyclic imine dibenzo[b,f][1,4]oxazepines with alkynes
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DOI: 10.1039/c6qo00545d
Abstract: An unexpected FeCl3-promoted reaction of cyclic imine dibenzo[b,f][1,4]oxazepines with alkynes was studied, leading to a series of 4-substituted 3-(2-hydroxyphenyl)-quinolines. A variety of substituted cyclic imines and terminal alkynes (arylacetylenes, conjugated enynes, and 1,3-diynes) were used… read more here.
Keywords: substituted hydroxyphenyl; imine dibenzo; promoted reaction; cyclic imine ... See more keywords
Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors
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DOI: 10.1111/jnc.13995
Abstract: We present an overview of the toxicological profile of the fastâacting, lipophilic macrocyclic imine toxins, an emerging family of organic compounds associated with algal blooms, shellfish contamination and neurotoxicity. Worldwide, shellfish contamination incidents are expanding;… read more here.
Keywords: acetylcholine receptors; family; nicotinic acetylcholine; cyclic imine ... See more keywords
Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors
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DOI: 10.3390/toxins10030097
Abstract: Prorocentrolides are members of the cyclic imine phycotoxins family. Their chemical structure includes a 26-membered carbo-macrocycle and a 28-membered macrocyclic lactone arranged around a hexahydroisoquinoline that incorporates the characteristic cyclic imine group. Six prorocentrolides are… read more here.
Keywords: type nachr; acetylcholine receptors; nicotinic acetylcholine; cyclic imine ... See more keywords