Cyclic Ion Mobility Mass Spectrometry Distinguishes Anomers and Open-Ring Forms of Pentasaccharides
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1007/s13361-019-02168-9
Abstract: AbstractThere is increasing biopharmaceutical interest in oligosaccharides and glycosylation. A key requirement for these sample types is the ability to characterize the chain length, branching, type of monomers, and importantly stereochemistry and anomeric configuration. Herein,… read more here.
Keywords: open ring; mass spectrometry; mobility; mass ... See more keywords
Exploiting Self-Association to Evaluate Enantiomeric Composition by Cyclic Ion Mobility–Mass Spectrometry
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DOI: 10.1021/acs.analchem.2c01212
Abstract: The characterization of enantiomers is an important analytical challenge in the chemical and life sciences. Thorough evaluation of the purity of chiral molecules is particularly required in the pharmaceutical industry where safety concerns are paramount.… read more here.
Keywords: mobility; composition; cyclic ion; mobility mass ... See more keywords
Unwrapping Wrap-around in Gas (or Liquid) Chromatographic Cyclic Ion Mobility-Mass Spectrometry.
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DOI: 10.1021/acs.analchem.2c02351
Abstract: Gas chromatography multiplexed with cyclic ion mobility mass spectrometry is a comprehensive two-dimensional separation technique that can resolve compounds that would otherwise coelute in a single-dimension separation. The cyclic geometry of the ion mobility cell… read more here.
Keywords: cyclic ion; ion mobility; wrap around; separation ... See more keywords
Advancing Cyclic Ion Mobility Mass Spectrometry Methods for Studying Biomolecules: Toward the Conformational Dynamics of Mega Dalton Protein Aggregates.
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DOI: 10.1021/acs.analchem.2c02406
Abstract: Native mass spectrometry is a powerful tool for the analysis of noncovalent complexes. When coupled with high-resolution ion mobility, this technique can be used to investigate the conformational changes induced in said complexes by different… read more here.
Keywords: cyclic ion; spectrometry; ion mobility; mass ... See more keywords
Ultrafast, Selective, and Highly Sensitive Nonchromatographic Analysis of Fourteen Cannabinoids in Cannabis Extracts, Δ8-Tetrahydrocannabinol Synthetic Mixtures, and Edibles by Cyclic Ion Mobility Spectrometry–Mass Spectrometry
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DOI: 10.1021/acs.analchem.3c05879
Abstract: The diversity of cannabinoid isomers and complexity of Cannabis products pose significant challenges for analytical methodologies. In this study, we developed a method to analyze 14 different cannabinoid isomers in diverse samples within milliseconds by… read more here.
Keywords: thc; spectrometry; mass spectrometry; cannabis ... See more keywords
Quantitative Analysis of Phosphorothioate Isomers in CRISPR sgRNA at Single-Residue Resolution Using Endonuclease Digestion Coupled with Liquid Chromatography Cyclic Ion Mobility Mass Spectrometry (LC/cIMS)
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DOI: 10.1021/acs.analchem.4c05304
Abstract: Phosphorothioate (PS) modifications in single-guided RNA (sgRNA) are crucial for genome editing applications using the CRISPR/Cas9 system. These modifications may enhance sgRNA stability, pharmacokinetics, and binding to targets, thereby facilitating the desired genetic alterations. Incorporating… read more here.
Keywords: endonuclease digestion; ion; ion mobility; mobility mass ... See more keywords
Beyond Liquid Chromatography: Cyclic Ion Mobility Spectrometry for Phosphorothioate Diastereomer Separation in siRNA.
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DOI: 10.1021/acs.analchem.5c03045
Abstract: Phosphorothioate (PS) modifications in small interfering RNA (siRNA) moieties enhance stability and therapeutic efficacy, but introduce diastereomeric heterogeneity, complicating structural characterization. Conventional chromatographic methods, such as ion-pair reversed-phase liquid chromatography, provide limited resolution of complex… read more here.
Keywords: separation; ion; mobility spectrometry; ion mobility ... See more keywords
Characterization of Sugammadex-Related Isomeric Cyclodextrin Impurities Using Cyclic Ion Mobility High-Resolution Mass Spectrometry
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DOI: 10.1021/jasms.4c00243
Abstract: Cyclic ion mobility–mass spectrometry (cIM-MS) is a powerful technique for separating and identifying isomeric mixtures of compounds. When coupled with chromatography, cIM-MS creates a multidimensional separation system, with high resolving power and peak capacity. In… read more here.
Keywords: separation; mass spectrometry; ion; ion mobility ... See more keywords