Catalytic Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Umpolung Cross-Mannich Reaction of Cyclic Ketimines.
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DOI: 10.1021/acs.orglett.0c01578
Abstract: A catalytic asymmetric umpolung cross-Mannich reaction of cyclic ketimines is realized. This protocol provides an efficient methodology for the facile synthesis of chiral vicinal tetrasubstituted diamines in high yields with excellent chemo-, regio-, diastereo-, and… read more here.
Keywords: mannich reaction; reaction cyclic; cyclic ketimines; umpolung cross ... See more keywords