Cyclic nucleotide selectivity of protein kinase G isozymes
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.4008
Abstract: The intrinsic activity of the C‐terminal catalytic (C) domain of cyclic guanosine monophosphate (cGMP)‐dependent protein kinases (PKG) is inhibited by interactions with the N‐terminal regulatory (R) domain. Selective binding of cGMP to cyclic nucleotide binding… read more here.
Keywords: cyclic nucleotide; selectivity; cnb domains; cgmp ... See more keywords
Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1582-5
Abstract: The non-canonical cyclic nucleotide cUMP and the phosphodiesterase PDE9A both occur in neuronal cells. Using HPLC-coupled tandem mass spectrometry, we characterized the kinetics of PDE9A-mediated cUMP hydrolysis. PDE9A is a low-affinity and high-velocity enzyme for… read more here.
Keywords: pde9a; cyclic nucleotide; canonical cyclic; non canonical ... See more keywords
Light-Activated Cyclic Nucleotide Phosphodiesterases
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.950
Abstract: The second messengers 3′,5′-cyclic adenosine monophosphate (cAMP) and cyclic 3′,5′-cyclic guanosine monophosphate (cGMP) mediate various biological responses like apoptosis, smooth muscle relaxation and vision. Cyclic-nucleotide-dependent processes have been analyzed with spatiotemporal resolution through optogenetics. In… read more here.
Keywords: cyclic nucleotide; light activated; phosphodiesterase; activated cyclic ... See more keywords
Altered cyclic nucleotide-binding and pore opening in a diseased human HCN4 channel.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.02.035
Abstract: A growing number of nonsynonymous mutations in the human HCN4 channel gene, the major component of the funny channel of the sinoatrial node, are associated with disease but how they impact channel structure and function,… read more here.
Keywords: channel; nucleotide binding; cyclic nucleotide; human hcn4 ... See more keywords
Cyclic nucleotide phosphodiesterases (PDEs) and endothelial function in ischaemic stroke. A review.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.05.011
Abstract: BACKGROUND Endothelial dysfunction is a hallmark of cerebrovascular disease, including ischemic stroke. Modulating endothelial signalling by cyclic nucleotides, cAMP and cGMP, is a potential therapeutic target in stroke. Inhibitors of the cyclic nucleotide degrading phosphodiesterase… read more here.
Keywords: cerebral endothelial; endothelial function; cyclic nucleotide; review ... See more keywords
Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide–gated and ryanodine 2 channels
Sign Up to like & getrecommendations! Published in 2018 at "Heart Rhythm"
DOI: 10.1016/j.hrthm.2017.12.027
Abstract: Background Aging is associated with an increased incidence of atrioventricular nodal (AVN) dysfunction. Objective The aim of this study was to investigate the structural and functional remodeling in the atrioventricular junction (AVJ) with aging. Methods… read more here.
Keywords: cyclic nucleotide; activated cyclic; nucleotide gated; hyperpolarization activated ... See more keywords
NMR Structures of Calmodulin Bound to Two Separate Regulatory Sites in the Retinal Cyclic Nucleotide-Gated Channel.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00378
Abstract: Retinal cyclic nucleotide-gated (CNG) channels (composed of three CNGA1 and one CNGB1 subunits) exhibit a Ca2+-induced reduction in channel open probability mediated by calmodulin (CaM). Defects in the Ca2+-dependent regulation of CNG channels may be… read more here.
Keywords: retinal cyclic; cam2; cam lobe; cam ... See more keywords
Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2300309120
Abstract: Calmodulin (CaM) regulates many ion channels to control calcium entry into cells, and mutations that alter this interaction are linked to fatal diseases. The structural basis of CaM regulation remains largely unexplored. In retinal photoreceptors,… read more here.
Keywords: structural basis; cam; cyclic nucleotide; nucleotide gated ... See more keywords
Evolution and Structural Characteristics of Plant Voltage-Gated K+ Channels
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DOI: 10.1105/tpc.18.00523
Abstract: Plant voltage-gated K+ channels have been referred to as “plant Shakers” in reference to animal Shaker channels, the first K+ channels identified. Recent advances in our knowledge of K+ channel evolution and structure have significantly… read more here.
Keywords: plant voltage; plant; cyclic nucleotide; gated channels ... See more keywords
The hyperpolarization‐activated cyclic nucleotide‐gated 4 channel as a potential anti‐seizure drug target
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15088
Abstract: Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels are encoded by four genes (HCN1–4) with distinct biophysical properties and functions within the brain. HCN4 channels activate slowly at robust hyperpolarizing potentials, making them more likely to be engaged… read more here.
Keywords: cyclic nucleotide; activated cyclic; nucleotide gated; hyperpolarization activated ... See more keywords
Liraglutide increases islet Ca2+ oscillation frequency and insulin secretion by activating hyperpolarization‐activated cyclic nucleotide‐gated channels
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14747
Abstract: To determine whether hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels impact glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) modulation of islet Ca2+ handling and insulin secretion. read more here.
Keywords: activated cyclic; insulin secretion; hyperpolarization activated; cyclic nucleotide ... See more keywords