Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium.
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DOI: 10.1021/acs.jnatprod.6b00907
Abstract: Integrating LC-MS/MS molecular networking and bioassay-guided fractionation enabled the targeted isolation of a new and bioactive cyclic octapeptide, samoamide A (1), from a sample of cf. Symploca sp. collected in American Samoa. The structure of… read more here.
Keywords: octapeptide samoamide; cytotoxic; cyclic octapeptide; molecular networking ... See more keywords
Total Synthesis of Clausenain, a Cyclic Octapeptide and its Analog for Anticancer Activity
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DOI: 10.5530/ijper.54.2s.90
Abstract: Keeping in mind requisite of today’s era for development of new anticancer drugs, synthesis of a phenyl alanine rich cyclic octapeptide Clausenain and its analog by solution phase technique is described here. It was done… read more here.
Keywords: cyclic octapeptide; clausenain; octapeptide analog; anticancer ... See more keywords