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Published in 2020 at "Peptide Science"
DOI: 10.1002/pep2.24204
Abstract: Cyclic peptides discovered by genetically encoded library technologies have emerged as a class of promising molecules in chemical biology and drug discovery. Here we review the cyclic peptides identified through these techniques reported in the…
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Keywords:
library technologies;
cyclic peptide;
encoded library;
genetically encoded ... See more keywords
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Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9504-2_5
Abstract: Peptide cyclization can improve stability, conformational constraint, and compactness. However, apart from beta-turn structures, which are well incorporated into cyclic peptides (CPs), many primary peptide structures and functions are markedly altered by cyclization. Accordingly, to…
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Keywords:
peptide;
cyclic peptide;
opportunities challenges;
computational opportunities ... See more keywords
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Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9504-2_8
Abstract: Click chemistry is a powerful tool in constraining peptides into their active conformations. This chapter presents recent advancements involving the use of copper-catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC), better known as "click reaction" in the design…
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Keywords:
click chemistry;
peptide drug;
chemistry cyclic;
cyclic peptide ... See more keywords
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Published in 2018 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-018-3712-x
Abstract: AbstractPresent molecular dynamics simulations indicate that the methanol component in a methanol/water mixture is more likely to be trapped in a cyclic peptide nanotube (CPNT), while water molecules tend to be present at the channel…
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Keywords:
methanol water;
methanol;
water;
cyclic peptide ... See more keywords
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Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9757-y
Abstract: Synthesis of artificial antibacterial peptides containing multiple disulfide bridges is of particular interest in bioorganic chemistry. In this paper, a straightforward on-resin synthesis of a cyclic peptide containing two disulfide bridges by orthogonal protection approach…
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Keywords:
disulfide bridges;
cyclic peptide;
peptide containing;
containing two ... See more keywords
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Published in 2018 at "Structural Chemistry"
DOI: 10.1007/s11224-018-1117-1
Abstract: In this work, the encapsulations of halide ions including F−, Cl−, and Br− by cyclic peptide nanocapsule as ion carrier (F−, Cl−, and Br− @(Ala4...Ala4)) were investigated using the dispersion corrected density functional theory (DFT)…
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Keywords:
cyclic peptide;
ala4 ala4;
ion;
peptide nanocapsule ... See more keywords
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Published in 2019 at "Journal of Biosciences"
DOI: 10.1007/s12038-019-9945-8
Abstract: Human bone morphogenetic protein 2 (BMP2) is a bone-growth regulatory factor involved in the formation of bone and cartilage, and has been recognized as an attractive therapeutic target for a variety of bone diseases and…
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Keywords:
type receptor;
cyclic peptide;
human bone;
bone ... See more keywords
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Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.11.029
Abstract: Interleukin-5 (IL-5) is a T-helper cell of subtype 2 cytokine involved in many aspects of eosinophil life. Eosinophilic granulocytes play a pathogenic role in the progression of atopic diseases, such as allergy, asthma and atopic…
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Keywords:
structural basis;
cyclic peptide;
inhibition;
peptide af17121 ... See more keywords
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Published in 2017 at "Journal of Membrane Science"
DOI: 10.1016/j.memsci.2017.04.060
Abstract: In this study, molecular simulation was used to explore the structural characteristics and transport performances of cyclic peptide nanotubes (CPNTs). A molecular dynamics (MD) technique was used to construct four different molecular models of nanotubes:…
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Keywords:
water;
cyclic peptide;
simulation;
functional groups ... See more keywords
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Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.05.045
Abstract: Abstract Elastin is a vital extracellular matrix protein, which is known for providing elasticity in numerous tissues. It is formed by the self-assembly and subsequent crosslinking of elastin precursor, tropoelastin. Two tetrafunctional, pyridinium-based amino acids…
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Keywords:
elucidation;
elucidation elastin;
cyclic peptide;
containing cyclic ... See more keywords
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Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00063
Abstract: Rod-shaped nanoparticles have been identified as promising drug delivery candidates. In this report, the in vitro cell uptake and in vivo pharmacokinetic/bio-distribution behavior of molecular bottle-brush (BB) and cyclic peptide self-assembled nanotubes were studied in…
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Keywords:
cyclic peptide;
polymeric nanotubes;
drug delivery;
nanotubes drug ... See more keywords