Computational investigation of retro‐isomer equilibrium structures: Intrinsically disordered, foldable, and cyclic peptides
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13558
Abstract: We use all‐atom modeling and advanced‐sampling molecular dynamics simulations to investigate quantitatively the effect of peptide bond directionality on the equilibrium structures of four linear (two foldable, two disordered) and two cyclic peptides. We find… read more here.
Keywords: retro; computational investigation; cyclic peptides; equilibrium structures ... See more keywords
Facile de Novo Sequencing of Tetrazine‐Cyclized Peptides through UV‐Induced Ring‐Opening and Cleavage from the Solid Phase
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200590
Abstract: While most FDA‐approved peptide drugs are cyclic, the robust cyclization chemistry of peptides and the deconvolution of cyclic peptide sequences by using tandem mass spectrometry render cyclic peptide drug discovery difficult. Here we present the… read more here.
Keywords: sequencing tetrazine; cyclic peptides; novo sequencing; solid phase ... See more keywords
Structural diversity in de novo cyclic peptide ligands from genetically encoded library technologies
Sign Up to like & getrecommendations! Published in 2020 at "Peptide Science"
DOI: 10.1002/pep2.24204
Abstract: Cyclic peptides discovered by genetically encoded library technologies have emerged as a class of promising molecules in chemical biology and drug discovery. Here we review the cyclic peptides identified through these techniques reported in the… read more here.
Keywords: library technologies; cyclic peptide; encoded library; genetically encoded ... See more keywords
Preparation of Bacterial Cell-Surface Displayed Semisynthetic Cyclic Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1689-5_11
Abstract: Semisynthetic cyclic peptides bearing both non-proteinogenic and genetically encoded amino acids are excellent ligands for peptide-based drug discovery. While semisynthesis expands the chemical space, genetic encoding allows access to a large library via randomization at… read more here.
Keywords: cyclic peptides; semisynthetic cyclic; cell surface; bacterial cell ... See more keywords
Three Methods for the Solution Phase Synthesis of Cyclic Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1689-5_4
Abstract: Cyclic peptides, which often exhibit interesting biological properties, can be obtained by macrolactamization of adequately protected linear peptide chains. Because of the remarkable biological properties, methods for the efficient cyclization of peptides are of high… read more here.
Keywords: phase synthesis; three methods; synthesis cyclic; methods solution ... See more keywords
Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein-Protein Interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9504-2_5
Abstract: Peptide cyclization can improve stability, conformational constraint, and compactness. However, apart from beta-turn structures, which are well incorporated into cyclic peptides (CPs), many primary peptide structures and functions are markedly altered by cyclization. Accordingly, to… read more here.
Keywords: peptide; cyclic peptide; opportunities challenges; computational opportunities ... See more keywords
Design of Cyclic Peptides as Protein Recognition Motifs.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9504-2_6
Abstract: Protein-protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Linear peptide drugs, however, can be applied therapeutically as protein recognition motifs only to a limited extent… read more here.
Keywords: protein recognition; design cyclic; recognition motifs; peptides protein ... See more keywords
Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications
Sign Up to like & getrecommendations! Published in 2017 at "Peptides"
DOI: 10.1016/j.peptides.2017.06.002
Abstract: &NA; Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti‐inflammation, anti‐proliferative, anti‐hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and… read more here.
Keywords: antibacterial antifungal; structural diversity; marine cyclic; molecular mechanisms ... See more keywords
Inhibition of Ice Recrystallization by Nanotube-Forming Cyclic Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01267
Abstract: While most native ice-binding proteins are rigid, artificial (macro)molecular ice-binders are usually flexible. Realizing a regular array with precisely positioned ice-binding motifs on synthetic proteins, (macro)molecular ice-binders are thus challenging. Here, we exploit the predictable… read more here.
Keywords: cyclic peptides; ice; spectroscopy; ice recrystallization ... See more keywords
Exploration of Structured Symmetric Cyclic Peptides as Ligands for Metal-Organic Frameworks
Sign Up to like & getrecommendations! Published in 2022 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.2c02597
Abstract: Despite remarkable advances in the assembly of highly structured coordination polymers and metal–organic frameworks, the rational design of such materials using more conformationally flexible organic ligands such as peptides remains challenging. In an effort to… read more here.
Keywords: cyclic peptides; organic frameworks; coordination; metal organic ... See more keywords
Orally Absorbed Cyclic Peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.6b00838
Abstract: Peptides and proteins are not orally bioavailable in mammals, although a few peptides are intestinally absorbed in small amounts. Polypeptides are generally too large and polar to passively diffuse through lipid membranes, while most known… read more here.
Keywords: oral bioavailability; orally absorbed; absorbed cyclic; cyclic peptides ... See more keywords