Diastereoselective Synthesis of Cyclic and Spirocyclic Quaternary Carbons via Iron-Catalyzed Ring Contraction of Cyclic Ketones: A Formal Synthesis of Perhydrohistrionicotoxin.
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DOI: 10.1021/acs.orglett.5c02888
Abstract: The iron-catalyzed hydrogen atom transfer (HAT)-initiated Dowd-Beckwith rearrangement presents a new approach for synthesizing cyclic and spirocyclic quaternary carbons from readily available β-keto esters and cyclic diketones with high yields. This reaction proceeds in a… read more here.
Keywords: spirocyclic quaternary; quaternary carbons; cyclic spirocyclic; synthesis ... See more keywords