Cyclic stretch regulates immune responses via tank‐binding kinase 1 expression in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13526
Abstract: Macrophages distributed in tissues throughout the body contribute to homeostasis. In the inflammatory state, macrophages undergo mechanical stress that regulates the signal transduction of immune responses and various cellular functions. However, the effects of the… read more here.
Keywords: stretch; immune responses; cyclic stretch; tank binding ... See more keywords
Numerical predictions of shear stress and cyclic stretch in pulmonary hypertension due to left heart failure
Sign Up to like & getrecommendations! Published in 2022 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-021-01538-1
Abstract: Isolated post-capillary pulmonary hypertension (Ipc-PH) occurs due to left heart failure, which contributes to 1 out of every 9 deaths in the United States. In some patients, through unknown mechanisms, Ipc-PH transitions to combined pre-/post-capillary… read more here.
Keywords: cyclic stretch; due left; shear stress; left heart ... See more keywords
Combined effects of cyclic stretch and TNF-α on the osteogenic differentiation in MC3T3-E1 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2021.105222
Abstract: OBJECTIVE The study aimed to investigate the combined effects of cyclic stretch and tumor necrosis factor-alpha (TNF-α) on the osteogenic differentiation of MC3T3-E1 cells and the role of the nuclear factor-kappaB (NF-κB) signaling pathway in… read more here.
Keywords: tnf; cyclic stretch; osteogenic differentiation; mc3t3 cells ... See more keywords
Cyclic stretch promotes vascular homing of endothelial progenitor cells via Acsl1 regulation of mitochondrial fatty acid oxidation.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219630120
Abstract: Endothelial progenitor cells (EPCs) play an important role in vascular repair and re-endothelialization after vessel injury. EPCs in blood vessels are subjected to cyclic stretch (CS) due to the pulsatile pressure, but the role of… read more here.
Keywords: endothelial progenitor; acid oxidation; cyclic stretch; progenitor cells ... See more keywords
Naringin Inhibits Apoptosis Induced by Cyclic Stretch in Rat Annular Cells and Partially Attenuates Disc Degeneration by Inhibiting the ROS/NF-κB Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6179444
Abstract: Oxidative stress and apoptosis play important roles in the pathogenesis of various degenerative diseases. Previous studies have shown that naringin can exert therapeutic effects in multiple degenerative diseases by resisting oxidative stress and inhibiting apoptosis.… read more here.
Keywords: cyclic stretch; oxidative stress; apoptosis; degeneration ... See more keywords
Mechanical cyclic stretch of the respiration and in vitro microvascular remodeling
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa4229
Abstract: Abstract Introduction: In addition to mechanical forces caused by blood flow, lung vascular networks undergo additional forces in the form of cyclic stretch from respiration. These forces act on the microvascular wall and play an… read more here.
Keywords: microvasculature; stretch; mechanical cyclic; cyclic stretch ... See more keywords
Cyclic stretch induced oxidative stress by mitochondrial and NADPH oxidase in retinal pigment epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "BMC Ophthalmology"
DOI: 10.1186/s12886-019-1087-0
Abstract: BackgroundVitreomacular adhesion (VMA) has been reported to associated with age-related macular degeneration (AMD). Understanding the mechanisms underlying cyclic stretch induced in retinal pigment epithelial cells (RPE) may be important for the treatment of VMA-related AMD.MethodCyclic… read more here.
Keywords: epithelial cells; stretch; pigment epithelial; stretch induced ... See more keywords
Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells
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DOI: 10.1371/journal.pone.0184770
Abstract: Interleukin 33 (IL-33), an inflammatory and mechanically responsive cytokine, is an important component of a TLR4-dependent innate immune process in mucosal epithelium. Although TLR4 also plays a role in sensing biomechanical stretch, a pathway of… read more here.
Keywords: hmgb1; stretch; stretch induced; cyclic stretch ... See more keywords
Basal Vascular Smooth Muscle Cell Tone in eNOS Knockout Mice Can Be Reversed by Cyclic Stretch and Is Independent of Age
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.882527
Abstract: Introduction and Aims: Endothelial nitric oxide synthase (eNOS) knockout mice develop pronounced cardiovascular disease. In the present study, we describe the alterations in aortic physiology and biomechanics of eNOS knockout and C57Bl/6 control mice at… read more here.
Keywords: stretch; stiffness; enos knockout; age ... See more keywords
Three-Motorized-Stage Cyclic Stretching System for Cell Monitoring Based on Chamber Local Displacement Waveforms
Sign Up to like & getrecommendations! Published in 2019 at "Applied Sciences"
DOI: 10.3390/app9081560
Abstract: Researchers have developed a cell stretching device to mimic the in vivo mechanical environment in vitro in order to investigate cell mechanotransduction. Cyclic stretch is involved in lengthening and relaxation phases. Cells may respond to… read more here.
Keywords: three motorized; cell; cyclic stretch; motorized stage ... See more keywords
Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22116044
Abstract: SGLT-2i’s exert direct anti-inflammatory and anti-oxidative effects on resting endothelial cells. However, endothelial cells are constantly exposed to mechanical forces such as cyclic stretch. Enhanced stretch increases the production of reactive oxygen species (ROS) and… read more here.
Keywords: reactive oxygen; stretch; barrier dysfunction; oxygen species ... See more keywords