Palladium‐Catalyzed Highly Enantioselective Arylation of Cyclic N‐Sulfonyl α‐Ketimino Esters towards the Synthesis of α‐Quaternary Chiral Amino Acid Derivatives
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DOI: 10.1002/cctc.201901933
Abstract: We have developed a highly effective palladium/PHOX catalyst system for efficient asymmetric 1,2‐addition of arylboronic acids to six‐membered 1,2,6‐thiadiazine‐1,1‐dioxide type cyclic N‐sulfonyl α‐iminoesters. The protocol allows convenient synthesis of a variety of nearly optically pure… read more here.
Keywords: synthesis; amino acid; acid derivatives; cyclic sulfonyl ... See more keywords
PdII‐Catalyzed Spiroannulation of Cyclic N‐Sulfonyl Ketimines with Aryl Iodides through C–H Bond Activation
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DOI: 10.1002/ejoc.201700569
Abstract: A new strategy has been developed for the first time for the synthesis of spirofluorenyl benzosultams through the annulation of aryl iodides with cyclic N-sulfonyl ketimines. This method involves a readily available Pd(II) catalyst for… read more here.
Keywords: pdii catalyzed; aryl iodides; catalyzed spiroannulation; activation ... See more keywords
Catalyst-controlled diastereoselective ring-opening formal [3+2]-cycloadditions of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines
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DOI: 10.1007/s11426-019-9760-7
Abstract: A diastereoselectivity-controllable formal [3+2]-cycloaddition of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines is developed, affording the corresponding tricyclic oxazolidine derivatives in moderate to excellent yields with excellent diastereoselectivities in the presence of palladium(0) or scandium(III)… read more here.
Keywords: catalyst controlled; sulfonyl imines; oxirane diesters; cyclic sulfonyl ... See more keywords
Synthesis of Sultams and Cyclic N-Sulfonyl Ketimines via Iron-Catalyzed Intramolecular Aliphatic C-H Amidation.
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DOI: 10.1021/acs.orglett.9b01732
Abstract: Cyclic sulfonamides (sultams) play a unique role in drug discovery and synthetic chemistry. A direct synthesis of sultams by an intramolecular C(sp3)-H amidation reaction using an iron complex in situ derived from Fe(ClO4)2 and aminopyridine… read more here.
Keywords: iron catalyzed; synthesis sultams; cyclic sulfonyl; iron ... See more keywords