CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13438
Abstract: Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by distinctive structural features, but their partner CDKs remain elusive.… read more here.
Keywords: cell; cdk6; cancer cell; cyclin ... See more keywords
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Oncology"
DOI: 10.1002/1878-0261.70085
Abstract: Cyclins D could be a unifying event in multiple myeloma (MM), even though MM is not typically considered a proliferative disease. In this study, we hypothesized that cyclins D might have additional roles in the… read more here.
Keywords: multiple myeloma; cell cycle; cyclin pathogenesis; cell ... See more keywords
Notch signaling‐induced cyclin d1 in diabetes ameliorating effects of the isolated polysaccharide from Rosa canina: In vitro and in vivo studies
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3755
Abstract: Notch signaling has a role in the expansion of the pancreas and the pathogenesis of diabetes. Modulation of Notch signaling by natural products seems to pave the way for treating diabetes. This research aimed to… read more here.
Keywords: notch signaling; diabetes ameliorating; isolated polysaccharide; cyclin ... See more keywords
Upregulation of cyclin D1 can act as an independent prognostic marker for longer survival time in human nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23298
Abstract: Cyclin D1 is an essential part of oncogenic transformation. We previously proved that cyclin D1 was upregulated in nasopharyngeal carcinoma (NPC) and promoted the NPC cell proliferation. But the association between cyclin D1 and the… read more here.
Keywords: cyclin act; upregulation cyclin; act independent; cyclin ... See more keywords
Simvastatin induces G1 arrest by up‐regulating GSK3β and down‐regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26156
Abstract: Simvastatin (SIM), a widely used cholesterol‐lowering drug, also exhibits tumor‐suppressive potentials in several types of malignancy. Colorectal cancer (CRC), the third most common malignant neoplasm, accounts for the second most leading cause of cancer‐related deaths… read more here.
Keywords: cdk4 cyclin; colorectal cancer; cyclin; cancer cells ... See more keywords
Targeting MYO1B impairs tumorigenesis via inhibiting the SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30831
Abstract: Myosin‐related proteins play an important role in cancer progression. However, the clinical significance, biological functions, and mechanisms of myosin 1B (MYO1B), in esophageal squamous cell carcinoma (ESCC) remain unclear. The clinical relevance of MYO1B, SNAI2,… read more here.
Keywords: cell carcinoma; snai2 cyclin; squamous cell; esophageal squamous ... See more keywords
HPV‐16/18 E6‐induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23292
Abstract: Oncogenic high‐risk human papillomavirus (HR‐HPV) infection causes a majority of cases of cervical cancer and pre‐cancerous cervical lesions. However, the mechanisms underlying the direct evolution from HPV‐16/18‐infected epithelium to cervical intraepithelial neoplasia (CIN) III, which… read more here.
Keywords: cervical cancer; cyclin; expression; hpv ... See more keywords
Molecular crosstalk between cancer and neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03428-3
Abstract: The progression of cancers and neurodegenerative disorders is largely defined by a set of molecular determinants that are either complementarily deregulated, or share remarkably overlapping functional pathways. A large number of such molecules have been… read more here.
Keywords: cancer neurodegenerative; neurodegenerative diseases; cyclin; molecular crosstalk ... See more keywords
Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0254-0
Abstract: Tsushima leopard cat is the subspecies of Amur cats, and it is classified as the most highest class of critically endangered animals. Although the protection activity is highly recognized, the number of animals is decreasing… read more here.
Keywords: cat prionailurus; cyclin; critically endangered; leopard cat ... See more keywords
Cyclin A in nonfunctioning pituitary adenomas
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DOI: 10.1007/s12020-020-02402-5
Abstract: Purpose Assess cyclin A in nonfunctioning pituitary adenomas (NFPA) and compare its expression in non-invasive and non-proliferative tumors with invasive and proliferative tumors (12× higher risk of recurrence). Methods Quantitative real time polymerase chain reaction… read more here.
Keywords: pituitary adenomas; adenomas; cyclin; non invasive ... See more keywords
Prognostic Value of Cyclin D1 and CD44 Expression in Gastric Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-018-0079-2
Abstract: BackgroundWorldwide, gastric carcinoma (GC) is the 5th most common malignancies in both sexes representing 6.8% of the total fatalities and is the 3rd leading cause of cancer death representing 8.8% of total fatalities. In Egypt,… read more here.
Keywords: cyclin; expression; cancer; cell ... See more keywords