Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
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DOI: 10.1002/cmdc.201700663
Abstract: 4‐Anilinoquinolines were identified as potent and narrow‐spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and bacterial entry into host cells. Optimization of the 4‐anilino group and the 6,7‐quinoline substituents produced… read more here.
Keywords: associated kinase; kinase; identification optimization; cyclin associated ... See more keywords
Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00613
Abstract: There is an urgent need for strategies to combat dengue and other emerging viral infections. We reported that cyclin G-associated kinase (GAK), a cellular regulator of the clathrin-associated host adaptor proteins AP-1 and AP-2, regulates… read more here.
Keywords: associated kinase; gak; kinase gak; cyclin associated ... See more keywords