Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02045
Abstract: The CDK8-cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C remains undruggable. Modulators regulating cyclin C activity directly are still under development. Here, a series of hydrophobic tagging-based degraders of the… read more here.
Keywords: cdk8 cyclin; molecule; degrader; cyclin complex ... See more keywords
Abstract 872: Deciphering the activation mechanism of CDK4/cyclin-D complex that differs from the CDK2/cyclin-E complex
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-872
Abstract: Cyclin-dependent protein kinases (CDKs) regulate the eukaryotic cell cycle progression. Dysregulated cell cycle leading to unscheduled cell proliferation is a characteristic of many cancer subtypes. Since some tumor cells require specific interphase CDKs for proliferation,… read more here.
Keywords: cancer; cdk4 cyclin; activation mechanism; cyclin complex ... See more keywords
Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex
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DOI: 10.1371/journal.pone.0196651
Abstract: Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6. To understand the binding behavior of flavonoids that inhibit the… read more here.
Keywords: behavior flavonoids; cyclin complex; cyclin; binding behavior ... See more keywords