The emerging roles of the CDK/cyclin complexes in antiviral innate immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27554
Abstract: More than 20 members of the human Cyclin-dependent kinases (CDKs) family share the feature of being activated by cyclins. CDKs have been involved in diverse biological processes, such as cell cycle, transcription, DNA damage response,… read more here.
Keywords: cdk cyclin; cyclin complexes; antiviral innate; innate immunity ... See more keywords
Tetrahydroindazole inhibitors of CDK2/cyclin complexes.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113232
Abstract: Over 50 tetrahydroindazoles were synthesized after 7-bromo-3,6,6-trimethyl-1-(pyridin-2-yl)-5,6,7,7a-tetrahydro-1H-indazol-4(3aH)-one (3) was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogues… read more here.
Keywords: inhibitors cdk2; tetrahydroindazole inhibitors; cyclin; cdk2 cyclin ... See more keywords