The cyclin‐dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity
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DOI: 10.1002/1873-3468.14434
Abstract: p27Kip1 functions to coordinate cell cycle progression through the inhibition of cyclin‐dependent kinase (CDK) complexes. p27Kip1 also exerts distinct activities beyond CDK‐inhibition, including functioning as a transcriptional regulator. The aryl hydrocarbon receptor (AhR) is a… read more here.
Keywords: hydrocarbon receptor; p27kip1; dependent kinase; cyclin dependent ... See more keywords
Safety and efficacy profile of cyclin‐dependent kinases 4/6 inhibitor palbociclib in cancer therapy: A meta‐analysis of clinical trials
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DOI: 10.1002/cam4.1970
Abstract: Palbociclib is a small‐molecule, cyclin‐dependent kinase 4 and 6 inhibitor, which prevents phosphorylation of the retinoblastoma (Rb) protein and inhibits cell‐cycle progression from G1 to S phase. We performed this meta‐analysis to estimate the safety… read more here.
Keywords: cyclin dependent; safety efficacy; clinical trials; palbociclib cancer ... See more keywords
Cyclin‐dependent kinase 5 promotes the growth of tongue squamous cell carcinoma through the microRNA 513c‐5p/cell division cycle 25B pathway and is associated with a poor prognosis
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DOI: 10.1002/cncr.34136
Abstract: The objective of this study was to investigate the role and molecular mechanism of cyclin‐dependent kinase 5 (CDK5) in regulating the growth of tongue squamous cell carcinoma (TSCC). read more here.
Keywords: cell; tongue squamous; dependent kinase; squamous cell ... See more keywords
Evaluation of Absolute Oral Bioavailability and Bioequivalence of Ribociclib, a Cyclin‐Dependent Kinase 4/6 Inhibitor, in Healthy Subjects
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DOI: 10.1002/cpdd.853
Abstract: Ribociclib, a selective and potent cyclin‐dependent kinase 4/6 inhibitor, has demonstrated safety and efficacy in combination with endocrine therapy in hormone receptor‐positive, human epidermal growth factor receptor‐2‐negative advanced breast cancer. In 2 open‐label crossover studies… read more here.
Keywords: bioequivalence; cyclin dependent; bioavailability; kinase inhibitor ... See more keywords
T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis
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DOI: 10.1002/ddr.21977
Abstract: Combination of cyclin‐dependent kinases (CDKs) and histone deacetylases (HDACs) inhibitors may have statistical synergy in suppressing cancer cell proliferation. Herein, a novel CDKs/HDACs dual inhibitor T‐17 was rationally designed, synthesized, and evaluated. Our results demonstrated… read more here.
Keywords: cell; dual inhibitor; cyclin dependent; histone deacetylases ... See more keywords
Cyclin‐dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression
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DOI: 10.1002/glia.24186
Abstract: Mechanisms regulating oligodendrocyte differentiation, developmental myelination and myelin maintenance in adulthood are complex and still not completely described. Their understanding is crucial for the development of new protective or therapeutic strategies in demyelinating pathologies such… read more here.
Keywords: myelination; dependent kinase; myelin maintenance; cyclin dependent ... See more keywords
Dependency of Cholangiocarcinoma on Cyclin D–Dependent Kinase Activity
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DOI: 10.1002/hep.30704
Abstract: Cholangiocarcinoma (CCA) is a bile duct cancer with a very poor prognosis. Currently, there is no effective pharmacological treatment available for it. We showed that CCA ubiquitously relies on cyclin‐dependent kinases 4 and 6 (CDK4/6)… read more here.
Keywords: cyclin dependent; cdk4; cholangiocarcinoma; cca ... See more keywords
Inhibited histone deacetylase 3 ameliorates myocardial ischemia–reperfusion injury in a rat model by elevating microRNA‐19a‐3p and reducing cyclin‐dependent kinase 2
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DOI: 10.1002/iub.2402
Abstract: Over the years, the roles of microRNAs (miRNAs) and histone deacetylase 3 (HDAC3) in human diseases have been investigated. This study focused on the effect of miR‐19a‐3p and HDAC3 in myocardial ischemia–reperfusion (I/R) injury (MIRI)… read more here.
Keywords: cyclin dependent; myocardial ischemia; histone deacetylase; dependent kinase ... See more keywords
Cyclin‐dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway
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DOI: 10.1002/iub.2574
Abstract: Spermatogenesis is a complex process that requires precise regulation. Phosphorylation plays a role in spermatogenesis by regulating protein structure and activity. This study focused on cyclin‐dependent kinase 7 (CDK7), and explored its function and molecular… read more here.
Keywords: spermatogenesis; cdk7; cyclin dependent; dependent kinase ... See more keywords
A curious case of cyclin‐dependent kinases in neutrophils
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DOI: 10.1002/jlb.2ru1021-573r
Abstract: Neutrophils are terminally differentiated, short‐lived white blood cells critical for innate immunity. Although cyclin‐dependent kinases (CDKs) are typically related to cell cycle progression, increasing evidence has shown that they regulate essential functions of neutrophils. This… read more here.
Keywords: case cyclin; cycle; curious case; kinases neutrophils ... See more keywords
When cyclin‐dependent kinases meet viral infections, including SARS‐CoV‐2
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DOI: 10.1002/jmv.27719
Abstract: Cyclin‐dependent kinases (CDKs) are protein kinases that play a key role in cell division and transcriptional regulation. Recent studies have demonstrated the critical roles of CDKs in various viral infections. However, the molecular processes underpinning… read more here.
Keywords: viral infections; cyclin dependent; dependent kinases; kinases meet ... See more keywords