Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission
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DOI: 10.1091/mbc.e18-07-0463
Abstract: Mitochondria exist in an equilibrium between fragmented and fused states that shifts heavily toward fission in response to cellular damage. Nuclear-to-cytoplasmic cyclin C relocalization is essential for dynamin-related protein 1 (Drp1)–dependent mitochondrial fission in response… read more here.
Keywords: gtpase activity; cyclin directly; stress; cyclin ... See more keywords