Cyclin D1 is a mediator of gastrointestinal stromal tumor KIT-independence
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0894-3
Abstract: Oncogenic KIT or PDGFRA tyrosine kinase mutations are compelling therapeutic targets in most gastrointestinal stromal tumors (GISTs), and the KIT inhibitor, imatinib, is therefore standard of care for patients with metastatic GIST. However, some GISTs… read more here.
Keywords: kit independent; cyclin expression; kit; expression ... See more keywords
Histone Demethylase JARID1B Is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression via Demethylation of H3K27me3.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology research"
DOI: 10.3727/096504017x14939809845080
Abstract: JARID1B has been proven to be upregulated in many human malignancies and is correlated with tumor progression. However, its expression and clinical significance in osteosarcoma are still unclear. Thus, the aim of this study was… read more here.
Keywords: histone demethylase; cyclin expression; demethylase jarid1b; h3k27me3 ... See more keywords
HTLV-1 basic leucine zipper factor downregulates cyclin D1 expression via interactions with NF-κB.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2017.2868
Abstract: Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult T cell leukemia (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which is encoded by the minus-strand of the… read more here.
Keywords: htlv basic; cyclin expression; factor; hbz ... See more keywords