SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24802-5
Abstract: SAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the dNTP substrates. Yet, phosphorylation of T592 downregulates SAMHD1 antiviral activity, but not its… read more here.
Keywords: restriction; non cycling; sumoylation samhd1; cycling cells ... See more keywords
Characterization of slow-cycling cells in the mouse cochlear lateral wall
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DOI: 10.1371/journal.pone.0179293
Abstract: Cochlear spiral ligament fibrocytes (SLFs) play essential roles in the physiology of hearing including ion recycling and the generation of endocochlear potential. In adult animals, SLFs can repopulate after damages, yet little is known about… read more here.
Keywords: type slfs; spiral ligament; wall; lateral wall ... See more keywords
Slow-Cycling Cells in Glioblastoma: A Specific Population in the Cellular Mosaic of Cancer Stem Cells
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DOI: 10.3390/cancers14051126
Abstract: Glioblastoma (GBM) exhibits populations of cells that drive tumorigenesis, treatment resistance, and disease progression. Cells with such properties have been described to express specific surface and intracellular markers or exhibit specific functional features including being… read more here.
Keywords: cancer stem; cycling cells; slow cycling; stem cells ... See more keywords
Identification and characterization of slow-cycling cells in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5428
Abstract: Ewing sarcoma (ES) is an aggressive primary malignant bone tumor that predominantly affects children and young adults. Multimodal treatment approaches have markedly improved the survival of patients with localized ES. However, local recurrence and distant… read more here.
Keywords: ewing sarcoma; cycling cells; slow cycling; study ... See more keywords