Synthesis and biological evaluation of selected 7H-pyrrolo[2,3-d]pyrimidine derivatives as novel CDK9/CyclinT and Haspin inhibitors.
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DOI: 10.1016/j.cbi.2021.109643
Abstract: Protein kinases, including CDK9/CyclinT and Haspin, are regarded as potential drug targets in cancer therapy. Findings from a previous study suggested 7-azaindole as a privileged scaffold for producing inhibitors of CDK9/CyclinT and Haspin. Inspired by… read more here.
Keywords: pyrrolo pyrimidine; cyclint; pyrimidine derivatives; cyclint haspin ... See more keywords