Molecular Determinants of Carbocation Cyclisation in Bacterial Monoterpene Synthases
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DOI: 10.1002/cbic.202100688
Abstract: Monoterpene synthases are often promiscuous enzymes, yielding product mixtures rather than pure compounds due to the nature of the branched reaction mechanism involving reactive carbocations. Two previously identified bacterial monoterpene synthases, a linalool synthase (bLinS)… read more here.
Keywords: bacterial monoterpene; molecular determinants; monoterpene synthases; carbocation ... See more keywords
Intramolecular epoxide ring opening cyclisation reactions involving guanidines
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DOI: 10.1016/j.tet.2016.12.065
Abstract: The cyclisation of N-allyl- and N-homoallylguanidines using DMDO leading to the formation of novel 5- and 6-membered guanidine heterocycles is reported. Several of the products formed displayed weak inhibition of glycosidase enzymes. read more here.
Keywords: ring opening; epoxide ring; opening cyclisation; intramolecular epoxide ... See more keywords
Radical cyclisation studies of β-nitroamines from the nitro-Mannich reaction
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DOI: 10.1016/j.tet.2018.06.022
Abstract: Abstract A range of novel β-nitroacetamides with an alkenyl- or alkynyl tether were synthesized using the deprotonative or conjugate addition nitro-Mannich reaction. They were subjected to radical denitration-cyclisation with a 10 equivalent excess of tributyltin… read more here.
Keywords: mannich reaction; cyclisation studies; nitro mannich; radical cyclisation ... See more keywords
Asymmetric Synthesis of Pyrrolizidines, Indolizidines and Quinolizidines via a Double Reductive Cyclisation Protocol
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DOI: 10.1055/s-0036-1590975
Abstract: This account describes an overview of the asymmetric syntheses of pyrrolizidines, indolizidines and quinolizidines via a common double reductive cyclisation protocol. The highly diastereoselective conjugate addition of an enantiopure lithium amide to an α,β-unsaturated ester… read more here.
Keywords: indolizidines quinolizidines; asymmetric syntheses; pyrrolizidines indolizidines; reductive cyclisation ... See more keywords
Synthesis of 3-Phenylsulfonylcoumarins by Cyclisation of Phenyl Propiolates with Sulfinic Acids or Sodium Sulfinates
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DOI: 10.3184/174751918x15385227785338
Abstract: Methods for the synthesis of 3-phenylsulfonylcoumarins by radical sulfonylation cyclisation of phenyl propiolates with sulfinic acids or sodium sulfinates as sulfonyl sources have been developed. A combination of potassium persulfate as oxidant and silver nitrate… read more here.
Keywords: phenyl propiolates; cyclisation phenyl; synthesis phenylsulfonylcoumarins; cyclisation ... See more keywords