Defluorinative Cyclization of Enamides with Fluoroalkyl Halides Through Two Vicinal C(sp3)─F Bonds Functionalization
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DOI: 10.1002/advs.202404738
Abstract: Introducing distinctive functional groups to expand the structural diversity and improve the intrinsic properties of parent molecules has been an essential pursuit in organic chemistry. By using perfluoroalkyl halide (PFAH) as a nontraditional, readily available,… read more here.
Keywords: cyclization enamides; cyclization; sp3 bonds; defluorinative cyclization ... See more keywords
RhII‐Catalyzed Cyclization of Ester/Thioester‐Containing N‐Sulfonyl‐1,2,3‐triazoles: Facile Synthesis of Alkylidenephthalans and Alkylidenethiophthalans
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201600466
Abstract: A facile synthetic method to access alkylidenephthalan or alkylidenethiophthalan derivatives has been developed via a cyclization reaction from N-sulfonyl-1,2,3-triazole derivatives by Rhodium(II)-Catalyzed rearrangement. read more here.
Keywords: rhii catalyzed; catalyzed cyclization; cyclization; thioester containing ... See more keywords
Metal‐free stereoselective synthesis of tetrahydropyrans bearing adjacent quaternary and tertiary stereocenters by acid mediated cyclization
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DOI: 10.1002/ajoc.202400096
Abstract: A convenient route for the preparation of tetrahydropyran (THP) derivatives with a quaternary and tertiary vicinal stereocenters is reported. The atom economy acid‐catalyzed cyclization of allylsilyl alcohols provided polysubstituted tetrahydropyrans in good yields and excellent… read more here.
Keywords: quaternary tertiary; metal free; cyclization; stereoselective synthesis ... See more keywords
Novel Radical Cyclization Cascade for the Unified Synthesis of the Cedrane and Clovane Sesquiterpene Skeletons
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DOI: 10.1002/ajoc.202400242
Abstract: Radical cyclization cascade reactions of epoxycyclohexanes possessing alkene and alkyne side chains have been achieved. Sequential 5‐ or 6‐exo‐trig/5‐exo‐dig reactions triggered by epoxide ring opening with Cp2TiCl were found to provide a useful unified synthetic… read more here.
Keywords: cyclization; radical cyclization; novel radical; cedrane ... See more keywords
Dicarbofunctionalization of Alkenes/Alkynes via CAN‐Mediated Cyclization Reactions
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DOI: 10.1002/ajoc.202500326
Abstract: Ceric ammonium nitrate (CAN) was utilized to transform readily available terminal alkenes/alkynes to the corresponding chroman‐4‐one/chromenoquinoline analogues. Interestingly, the type of unsaturation on the substrate dictates the course of the CAN‐mediated cyclization reaction. With alkenes,… read more here.
Keywords: mediated cyclization; dicarbofunctionalization alkenes; alkynes via; cyclization ... See more keywords
Cascade C─H‐Alkenylation‐Intramolecular Aminative Cyclization of Benzylsulfonamides for Synthesis of Isoindoline Cores
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DOI: 10.1002/ajoc.202500379
Abstract: Several isoindoline‐core‐bearing compounds are pharmaceutically relevant due to their activity against a myriad of diseases. Traditionally, the isoindoline core is synthesized from benzylamines by two‐step synthesis involving ortho‐C─H alkenylation followed by acid‐ or metal‐catalyzed cyclization.… read more here.
Keywords: synthesis isoindoline; alkenylation; aminative cyclization; cyclization ... See more keywords
Access to Functionalized Pyridoindolones Enabled by Rh(III)‐Catalyzed C─H Alkenylation/Cyclization of Indoles with Alkynes
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DOI: 10.1002/ajoc.70220
Abstract: Herein, we report a traceless directing group assisted Rh(III)‐catalyzed C─H cyclization cascade of indoles and (arylprop‐2‐yn‐1‐yl)malonates under redox‐free reaction conditions, thus providing a concise access to structurally diverse functionalized pyridoindolones. This transformation proceed smoothly with… read more here.
Keywords: functionalized pyridoindolones; cyclization; pyridoindolones enabled; access functionalized ... See more keywords
Facile synthesis of indene and fluorene derivatives through AlCl3‐catalyzed cyclization of in situ formed iminium ions
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DOI: 10.1002/aoc.3863
Abstract: A simple AlCl3-catalyzed condensation/cyclization cascade process between aldehydes and sulfonamide is reported, in which two new bonds and one five-membered ring are simultaneously formed with water as the byproduct. This method provides a rapid access… read more here.
Keywords: indene fluorene; facile synthesis; cyclization; fluorene derivatives ... See more keywords
Dual Gold(I)‐catalyzed Cyclization of Dialkynyl Pyridinium Salts
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DOI: 10.1002/cctc.201700018
Abstract: Novel dialkynyl pyridines were synthesized and protected as alkyl salts for dual gold(I)‐catalyzed cycloisomerization. Different alkyl groups and counter ions were screened for the salts, with benzyl and hexafluorophosphate providing the best results. The cyclization… read more here.
Keywords: dual gold; cyclization; dialkynyl; gold catalyzed ... See more keywords
Catalytic Gas‐Phase Cyclization of Glycolate Esters: A Novel Route Toward Glycolide‐Based Bioplastics
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DOI: 10.1002/cctc.201801469
Abstract: A catalytic process to produce glycolide, the cyclic dimer of glycolic acid (GA), is proposed. Glycolide is the key building block of the biodegradable plastic polyglycolic acid. Instead of the current industrial two‐step route, which… read more here.
Keywords: glycolide; cyclization; glycolate; gas phase ... See more keywords
Nickel‐Catalyzed Sequential Dehydrogenation and Cyclization of 2‐Amino(Nitro)‐benzyl Alcohols with Alkyl Alcohols: Synthesis of C‐3‐Substituted Quinolines
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DOI: 10.1002/cctc.202300412
Abstract: We herein reported a general and efficient Ni‐catalyzed protocol for sequential double de‐hydrogenative cyclization of 2‐amino(nitro)‐benzyl alcohols with primary alcohols to C‐3‐substituted quinolines releasing water and dihydrogen as by products. As a special highlight, late… read more here.
Keywords: amino nitro; benzyl alcohols; nitro benzyl; cyclization amino ... See more keywords