K2S2O8/I2-Promoted Electrophilic Selenylative Cyclization To Access Seleno-Benzo[b]azepines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00387
Abstract: A novel and simple organoselenium-involved 7-membered cyclization to access diverse seleno-benzo[b]azepines has been developed. This protocol involves an electrophilic cyclization process and is accomplished under mild conditions. Discussion of the mechanism rationalizes the regioselectivity observed… read more here.
Keywords: cyclization access; seleno benzo; benzo azepines;
Tandem Hydroamination/Cyclization Access to N-2(5H)-Furanone Derivatives for COX-2 Inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.9b04041
Abstract: Several N-2(5H)-furanone compounds were synthesized successfully and were characterized systematically. Compounds bearing piperazine and trifluoromethyl moieties 1q were the best COX-2 inhibitors with ultrahigh selectivity index compared to celecoxib. read more here.
Keywords: tandem hydroamination; access furanone; furanone derivatives; cyclization access ... See more keywords