Construction of Spirolactams by Unexpected Oxidative Cyclization of Alkenyl Diynes via Copper Catalysis.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00319
Abstract: A copper-catalyzed oxidative cyclization of alkenyl N-propargyl ynamides is described. This protocol enables the practical synthesis of diverse spirocyclic γ-lactams bearing an exocyclic double bond with generally high Z/E selectivity in moderate to good yields.… read more here.
Keywords: catalysis; copper; cyclization alkenyl; oxidative cyclization ... See more keywords
Copper-catalyzed asymmetric cyclization of alkenyl diynes: method development and new mechanistic insights†
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02773e
Abstract: Metal carbenes have proven to be one of the most important and useful intermediates in organic synthesis, but catalytic asymmetric reactions involving metal carbenes are still scarce and remain a challenge. Particularly, the mechanistic pathway… read more here.
Keywords: copper; catalyzed asymmetric; cyclization alkenyl; asymmetric cyclization ... See more keywords
Electrophilic Intramolecular Cyclization of 1-(N-alkenyl)-6-methylpyrimidine-2,4-diones
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry and Chemical Technology"
DOI: 10.23939/chcht12.03.285
Abstract: Recently, the researchers have synthesized a series of heterocyclic compounds which are derivatives of oxazoles, thiazoles, imidazoles, pyridines, pyrimidines, benzimidazoles, benzothiazoles [1-6]. Such an interest in these heterocycles is caused by their rather high biological… read more here.
Keywords: electrophilic intramolecular; intramolecular cyclization; cyclization alkenyl; methylpyrimidine diones ... See more keywords