Lewis/Brønsted acid-mediated cyclization/amidation of 1,6-enynes with nitriles: access to 3-enamide substituted dihydrobenzofurans.
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DOI: 10.1039/d3cc00787a
Abstract: A novel Lewis- and Brønsted-acid mediated electrophilic addition cyclization/amidation reaction of 1,6-enynes with nitriles to synthesize 3-enamide-substituted dihydrobenzofurans has been developed. The transformation involves the addition of a Brønsted acid as the electrophilic reagent to… read more here.
Keywords: lewis nsted; acid mediated; nsted acid; cyclization ... See more keywords