Approach to Spirocyclohexadienes via Visible Light‐Mediated ipso‐Cyclization of Amino Acid Derivatives with N‐(2‐Phenyl)benzoyl Groups
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DOI: 10.1002/ajoc.202400140
Abstract: Spirocycles are important structural motifs, found in natural and pharmaceutical compounds, which have attracted considerable interest in modern drug discovery research. Herein, we describe the development of a visible light‐mediated ipso‐cyclization of amino acid derivatives… read more here.
Keywords: light mediated; mediated ipso; visible light; cyclization amino ... See more keywords
Nickel‐Catalyzed Sequential Dehydrogenation and Cyclization of 2‐Amino(Nitro)‐benzyl Alcohols with Alkyl Alcohols: Synthesis of C‐3‐Substituted Quinolines
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DOI: 10.1002/cctc.202300412
Abstract: We herein reported a general and efficient Ni‐catalyzed protocol for sequential double de‐hydrogenative cyclization of 2‐amino(nitro)‐benzyl alcohols with primary alcohols to C‐3‐substituted quinolines releasing water and dihydrogen as by products. As a special highlight, late… read more here.
Keywords: amino nitro; benzyl alcohols; nitro benzyl; cyclization amino ... See more keywords
Synthesis of 6-azaindoles via formal electrophilic [4+1]-cyclization of 3-amino-4-methyl pyridines: new frontiers of the diversity
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DOI: 10.1039/d3qo01937c
Abstract: A scalable and efficient synthesis of the 2-trifluoromethyl-3-trifluoroacetyl-6-azaindoles from 3-amino-4-methylpyridines under treatment with TFAA was disclosed. The reaction scope and limitation towards the pyridine and electrophilic components were investigated. Activation... read more here.
Keywords: cyclization amino; electrophilic cyclization; formal electrophilic; via formal ... See more keywords