B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the synthesis of 2,4,6-triarylpyridines
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.08.060
Abstract: Abstract The B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the construction of 2,4,6-triarylpyridines under metal-/solvent-free conditions has been successfully achieved. The advantages of this strategy include good functional group tolerance, low catalyst… read more here.
Keywords: deamination cyclization; cascade reaction; cyclization cascade; c6f5 catalyzed ... See more keywords
Functionalized Polyhydroquinolines from Amino Acids Using a Key One-Pot Cyclization Cascade and Application to the Synthesis of (±)-Δ7-Mesembrenone.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03323
Abstract: Substituted polyhydroquinolines are ubiquitous skeletal cores found in drugs and bioactive natural products. As a new route to access this motif, we successfully developed a one-pot cyclization cascade with high chemocontrol and diastereoselectivity. The sequence… read more here.
Keywords: amino acids; synthesis mesembrenone; functionalized polyhydroquinolines; cyclization cascade ... See more keywords
Mn(OAc)3-Promoted Sulfonation-Cyclization Cascade via the SO3- Radical: The Synthesis of Heterocyclic Sulfonates.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03510
Abstract: Herein we reported a Mn(OAc)3·2H2O promoted radical sulfonation from functionalized alkenes and potassium metabisulfite (K2S2O5). The reaction realized the construction of oxindole, quinolinone, isoquinoline-1,3-dione, or benzoxazine structural fragments and the introduction of sulfonic moieties in… read more here.
Keywords: sulfonation cyclization; oac promoted; sulfonation; cyclization cascade ... See more keywords
A dienamine-mediated deconjugative addition/cyclization cascade of γ,γ-disubstituted enals with carboxylic acid-activated enones: a rapid access to highly functionalized γ-lactones
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01367a
Abstract: An aminocatalytic deconjugative addition/cyclization cascade of γ,γ-disubstituted enals with carboxylic acid-activated enones was realized. The in situ generated dienamine species was regioselectively trapped at the α position by carboxylic acid-activated enones, leading to highly functionalized… read more here.
Keywords: activated enones; cyclization cascade; carboxylic acid; acid activated ... See more keywords
Nickel-Promoted Reductive Cyclization Cascade: A Short Synthesis of a New Aromatic Strigolactone Analogue
Sign Up to like & getrecommendations! Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1588804
Abstract: A stereospecific synthesis of the tetrahydro-2 H -indeno[1,2- b ]furan skeleton, which is embedded in bioactive aromatic strigolactones such as GR24, is realized by a nickel-mediated tandem cross-coupling for the first time. The observed cis… read more here.
Keywords: cascade short; nickel promoted; cyclization cascade; reductive cyclization ... See more keywords