Polar-Radical Cyclization Cascades with Magnesiated Nitriles.
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DOI: 10.1021/acs.orglett.3c01094
Abstract: Naphthalene converts magnesiated ω-alkenylnitriles into bi- and tricyclic ketones via a polar-radical addition-cyclization cascade. One-electron oxidation of magnesiated nitriles generates nitrile-stabilized radicals that cyclize onto a pendant olefin and then rebound onto the nitrile through… read more here.
Keywords: polar radical; radical cyclization; cyclization; cascades magnesiated ... See more keywords
Catalyst-Free Intramolecular Radical Cyclization Cascades initiated by direct homolysis of Csp3-Br under visible light
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DOI: 10.1039/d3gc00304c
Abstract: A visible light-driven carbon–carbon bond-forming cyclization cascades under metal- and catalyst-free conditions have been reported. The cascade is initiated through a transient alkyl radical intermediate that is formed by direct... read more here.
Keywords: catalyst free; free intramolecular; visible light; intramolecular radical ... See more keywords