Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization† †This work is dedicated to Prof. Ron Raines on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc01345h
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DOI: 10.1039/c9sc01345h
Abstract: Vinylphosphonites react in chemoselective Staudinger-phosphonite reactions (SPhR) with azides to form vinylphosphonamidates for the subsequent modification of cysteine residues in peptides and proteins. read more here.
Keywords: staudinger induced; vinylphosphonites staudinger; induced chemoselective; peptide cyclization ... See more keywords
Recent advances in metal catalyzed or mediated cyclization/functionalization of alkynes to construct isoxazoles
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DOI: 10.1039/d0qo00609b
Abstract: Isoxazoles and their derivatives represent privileged heteroaromatic motifs, which exhibit remarkable biological and pharmaceutical activities. Notably, metal catalyzed or mediated cyclization/functionalization of alkynes such as alkynone oxime ethers, acetylinic oximes, propargylic amino ethers, alkynyl nitrile… read more here.
Keywords: catalyzed mediated; mediated cyclization; cyclization functionalization; functionalization alkynes ... See more keywords