Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol.
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DOI: 10.1021/acschembio.7b00154
Abstract: The diterpene cyclase CotB2 catalyzes the cyclization of geranylgeranyl diphosphate (GGPP) to the tricyclic cyclooctat-9-en-7-ol, which is characterized by a 5-8-5-fused ring skeleton. We have previously proposed a cyclization cascade involving a unique carbon-carbon bond… read more here.
Keywords: geranylgeranyl diphosphate; cyclization geranylgeranyl; geranylgeranyl; cyclization ... See more keywords