Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa.
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DOI: 10.1021/acs.jmedchem.2c01080
Abstract: Factor XIIa (FXIIa) is a promising target for developing new drugs that prevent thrombosis without causing bleeding complications. A native cyclotide (MCoTI-II) is gaining interest for engineering FXIIa-targeted anticoagulants as this peptide inhibits FXIIa but… read more here.
Keywords: loop; mcoti; cyclization loop; factor xiia ... See more keywords